TB-Profiler result

Run: ERR4815472
Summary

Run ID: ERR4815472

Sample name:

Date: 20-10-2023 07:50:39

Number of reads: 1720775

Percentage reads mapped: 90.65

Strain: lineage4.9

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin R rrs n.888G>A (0.63)
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.63 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.65
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.41
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.44
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.88
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.9
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.73
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.74
rrs 1472579 n.734G>C non_coding_transcript_exon_variant 0.67
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.52
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.85
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.76
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.76
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.63
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.57
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.63
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.65
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.68
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.66
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.16
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.71
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.69
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.72
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.53
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.53
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.87
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.8
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.62
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.44
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.42
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.83
rrs 1472992 n.1147A>G non_coding_transcript_exon_variant 0.22
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.3
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.72
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.71
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.71
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.76
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.61
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.59
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.6
rrs 1473172 n.1327T>G non_coding_transcript_exon_variant 0.35
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.38
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.39
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.7
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.7
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.52
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.56
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.55
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.45
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154200 p.Tyr638His missense_variant 1.0
katG 2155745 p.Gly123Arg missense_variant 1.0
ahpC 2726142 c.-51G>A upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0