TB-Profiler result

Run: ERR4816711
Summary

Run ID: ERR4816711

Sample name:

Date: 20-10-2023 08:10:35

Number of reads: 1521892

Percentage reads mapped: 96.32

Strain: lineage4.1.1.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.1 Euro-American (X-type) X1;X2;X3 None 1.0
lineage4.1.1.1 Euro-American (X-type) X2 RD183 0.9
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
rpoC 765150 p.Gly594Glu missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.58
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.55
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.55
rrs 1472960 n.1115G>A non_coding_transcript_exon_variant 0.55
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.5
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.46
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.46
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.5
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.5
rrs 1472986 n.1141C>T non_coding_transcript_exon_variant 0.55
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.55
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.55
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.58
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.54
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.5
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.5
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.54
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.5
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.5
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.62
rrl 1476297 n.2640C>A non_coding_transcript_exon_variant 0.62
rrl 1476298 n.2641C>A non_coding_transcript_exon_variant 0.57
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.57
rrl 1476309 n.2652G>T non_coding_transcript_exon_variant 0.67
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.53
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiA 3641447 p.Thr302Met missense_variant 1.0
rpoA 3877553 p.Glu319Lys missense_variant 1.0
embC 4240897 c.1035C>G synonymous_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embB 4249408 c.2895G>A synonymous_variant 0.98
whiB6 4338595 c.-75delG upstream_gene_variant 1.0