TB-Profiler result

Run: ERR4817418
Summary

Run ID: ERR4817418

Sample name:

Date: 01-04-2023 14:58:58

Number of reads: 1162815

Percentage reads mapped: 99.71

Strain: lineage4.4.1.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.4 Euro-American S;T None 1.0
lineage4.4.1 Euro-American (S-type) S;T None 1.0
lineage4.4.1.1 Euro-American S;Orphans None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5791 c.552A>G synonymous_variant 0.1
gyrB 6570 p.Asp444Gly missense_variant 0.11
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7424 c.123G>T synonymous_variant 0.11
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7739 c.440_441delAG frameshift_variant 0.15
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491223 c.441C>A synonymous_variant 0.12
mshA 575684 p.Val113Leu missense_variant 0.13
rpoB 763261 p.Ala1152Val missense_variant 0.18
rpoC 763382 p.Asn5Tyr missense_variant 0.2
rpoC 763397 p.Leu10Phe missense_variant 0.12
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 778329 p.Pro51Leu missense_variant 0.12
mmpS5 778662 p.Asp82Asn missense_variant 0.11
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303185 p.Ser85Arg missense_variant 0.11
embR 1416222 p.Phe376Leu missense_variant 0.12
embR 1416232 p.Cys372Gly missense_variant 0.12
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1473266 n.1421A>C non_coding_transcript_exon_variant 1.0
rrl 1473617 n.-41T>C upstream_gene_variant 0.29
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102990 p.Val18Ala missense_variant 1.0
PPE35 2167701 p.Ala971Asp missense_variant 0.18
PPE35 2169840 p.Gly258Asp missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289586 c.-345T>C upstream_gene_variant 0.1
pncA 2289649 c.-408G>C upstream_gene_variant 0.11
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3448516 p.Phe5Ile missense_variant 0.11
Rv3083 3448608 c.105G>A synonymous_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612665 p.Val151Ala missense_variant 1.0
clpC1 4040366 c.339C>T synonymous_variant 0.2
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4247836 c.1323A>G synonymous_variant 1.0
embB 4248597 p.Glu695Gly missense_variant 0.13
embB 4249665 p.Thr1051Asn missense_variant 0.13
aftB 4267894 p.Ile315Val missense_variant 0.2
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408086 c.117C>G synonymous_variant 1.0
gid 4408314 c.-112G>T upstream_gene_variant 0.15
gid 4408317 c.-115T>C upstream_gene_variant 0.14