TB-Profiler result

Run: ERR4819561

Summary

Run ID: ERR4819561

Sample name:

Date: 20-10-2023 08:59:09

Number of reads: 1973828

Percentage reads mapped: 98.57

Strain: lineage4.1.2.1

Drug-resistance: Sensitive


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 0.99
lineage4.1.2 Euro-American T;H None 0.98
lineage4.1.2.1 Euro-American (Haarlem) T1;H1 RD182 0.99
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 0.98
fgd1 491591 p.Lys270Met missense_variant 1.0
mshA 575679 p.Asn111Ser missense_variant 1.0
rpoB 760115 c.309C>T synonymous_variant 0.98
rpoC 765150 p.Gly594Glu missense_variant 0.99
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 0.98
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.58
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.92
rrs 1472992 n.1147A>G non_coding_transcript_exon_variant 0.58
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.54
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.88
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.87
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.86
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.86
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.64
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.54
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.5
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.5
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.5
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.5
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.5
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.46
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.6
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.47
rrs 1473172 n.1327T>G non_coding_transcript_exon_variant 0.47
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.53
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.42
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.38
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
ethA 4328094 c.-621C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0