TB-Profiler result

Run: ERR4821771
Summary

Run ID: ERR4821771

Sample name:

Date: 2024-10-05T01:57:33.923490

Number of reads: 2301783

Percentage reads mapped: 99.71

Median coverage: 75.0

Strain: lineage4.1.2.1;lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.33
lineage4.1.2 Euro-American None 0.32
lineage4.1.2.1 Euro-American (Haarlem) RD182 0.36
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 0.68
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 936 c.936C>A synonymous_variant 0.37 isoniazid Not assoc w R - Interim
gyrB 5713 c.474C>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 0.42 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 0.39 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491591 p.Lys270Met missense_variant 0.39 pretomanid
delamanid Uncertain significance
clofazimine Not assoc w R
mshA 575679 p.Asn111Ser missense_variant 0.26 isoniazid Not assoc w R
ethionamide Not assoc w R
Rv0565c 657269 p.Ser68Pro missense_variant 0.22 ethionamide Uncertain significance
rpoB 760115 c.309C>T synonymous_variant 0.32 rifampicin Not assoc w R
rpoC 765150 p.Gly594Glu missense_variant 0.36 rifampicin Not assoc w R
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
tsnR 1854300 p.Leu232Pro missense_variant 0.28 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
PPE35 2167792 p.Ser941Ala missense_variant 0.18 pyrazinamide Uncertain significance
PPE35 2170201 p.Ala138Thr missense_variant 0.51 pyrazinamide Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2518076 c.-39C>T upstream_gene_variant 0.3 isoniazid
ribD 2986892 c.54C>T synonymous_variant 0.31 para-aminosalicylic_acid
Rv2680 2996085 c.-20G>A upstream_gene_variant 0.12 capreomycin Uncertain significance
Rv2680 2996301 p.His66Arg missense_variant 0.78 capreomycin Uncertain significance
ald 3086788 c.-32T>C upstream_gene_variant 0.34 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 0.24 rifampicin Not assoc w R
bedaquiline Uncertain significance
embC 4239298 c.-565C>T upstream_gene_variant 0.35 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 0.27 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.31 ethambutol Not assoc w R
embA 4244102 c.870A>G synonymous_variant 0.74 ethambutol Not assoc w R - Interim
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 0.39 kanamycin
capreomycin
amikacin