TB-Profiler result

Run: ERR4829623
Summary

Run ID: ERR4829623

Sample name:

Date: 01-04-2023 19:35:24

Number of reads: 3803048

Percentage reads mapped: 93.12

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.17
mshA 576113 p.Arg256Gly missense_variant 0.25
rpoC 764807 p.Arg480Cys missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.12
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.12
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.15
rrs 1472177 n.332C>T non_coding_transcript_exon_variant 0.11
rrs 1472210 n.365A>T non_coding_transcript_exon_variant 0.11
rrs 1472214 n.369C>G non_coding_transcript_exon_variant 0.12
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.13
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.13
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.14
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.1
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.1
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.15
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.15
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.19
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.14
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.12
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.1
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
rrl 1474016 n.359C>T non_coding_transcript_exon_variant 0.11
rrl 1474097 n.440C>A non_coding_transcript_exon_variant 0.1
rrl 1474359 n.702C>G non_coding_transcript_exon_variant 0.1
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.1
rrl 1474690 n.1033C>T non_coding_transcript_exon_variant 0.15
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.21
rrl 1474717 n.1060_1061insGCCAG non_coding_transcript_exon_variant 0.18
rrl 1474752 n.1096delA non_coding_transcript_exon_variant 0.17
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.16
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.13
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.12
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.1
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.12
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2170065 p.Ala183Gly missense_variant 0.24
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pepQ 2860159 p.Ala87Gly missense_variant 0.25
thyA 3074231 p.Asp81Asn missense_variant 1.0
fbiD 3339734 p.Ala206Gly missense_variant 0.43
Rv3083 3448497 c.-7T>A upstream_gene_variant 1.0
alr 3840764 c.657G>C synonymous_variant 1.0
embC 4242497 p.Arg879Gly missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246584 p.Arg24Pro missense_variant 0.1
embB 4248324 p.Ala604Gly missense_variant 0.22
whiB6 4338466 c.54_55delCG frameshift_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0