TB-Profiler result

Run: ERR501641
Summary

Run ID: ERR501641

Sample name:

Date: 01-04-2023 21:48:38

Number of reads: 1581254

Percentage reads mapped: 99.42

Strain: lineage4.3.2.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.3 Euro-American (LAM) mainly-LAM None 1.0
lineage4.3.2 Euro-American (LAM) LAM3 None 1.0
lineage4.3.2.1 Euro-American (LAM) LAM3 RD761 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5520 p.Pro94Leu missense_variant 1.0
gyrA 7222 c.-80C>T upstream_gene_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 490699 c.-84C>T upstream_gene_variant 0.17
rpoB 761881 p.Ala692Val missense_variant 0.14
rpoC 764995 c.1626C>G synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776723 p.Tyr586* stop_gained 0.2
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1304680 p.Val584Ile missense_variant 0.13
embR 1417129 c.219C>T synonymous_variant 0.12
atpE 1460995 c.-50A>G upstream_gene_variant 0.11
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472337 n.492C>T non_coding_transcript_exon_variant 1.0
rrl 1473855 n.198A>G non_coding_transcript_exon_variant 0.22
rrl 1474280 n.623C>A non_coding_transcript_exon_variant 0.18
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.29
rrl 1475019 n.1362T>G non_coding_transcript_exon_variant 0.17
rrl 1476199 n.2542G>T non_coding_transcript_exon_variant 0.18
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168297 c.2315delC frameshift_variant 0.18
PPE35 2170053 p.Thr187Ser missense_variant 0.19
PPE35 2170066 p.Ala183Thr missense_variant 0.21
PPE35 2170690 c.-78A>T upstream_gene_variant 0.25
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518222 c.108G>T synonymous_variant 1.0
eis 2715359 c.-27C>A upstream_gene_variant 0.17
folC 2746166 p.Ala478Val missense_variant 1.0
folC 2747537 p.Pro21Leu missense_variant 0.15
ribD 2987307 p.Ala157Pro missense_variant 0.19
Rv2752c 3066352 c.-161C>T upstream_gene_variant 0.12
thyA 3073868 p.Thr202Ala missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3086927 c.108G>A synonymous_variant 0.13
ald 3087539 c.720G>C synonymous_variant 0.11
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiB 3641955 p.Gly141Arg missense_variant 0.14
clpC1 4038287 c.2418C>T synonymous_variant 1.0
clpC1 4038857 c.1848C>A synonymous_variant 0.23
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4246471 p.Thr1080Ile missense_variant 0.13
embB 4246544 p.Thr11Pro missense_variant 0.18
embB 4246548 p.Pro12Gln missense_variant 0.2
embB 4246555 c.42G>C synonymous_variant 0.23
embB 4246556 p.Ala15Pro missense_variant 0.25
embB 4246563 p.Leu17Trp missense_variant 0.22
embB 4246567 c.54G>T synonymous_variant 0.22
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408156 p.Leu16Arg missense_variant 1.0