TB-Profiler result

Run: ERR5908228
Summary

Run ID: ERR5908228

Sample name:

Date: 2024-04-15T02:15:41.507519

Number of reads: 4424249

Percentage reads mapped: 81.36

Median coverage: 126.0

Strain: lineage4.3.3

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 0.98
lineage4 Euro-American None 0.96
lineage4.3.3 Euro-American (LAM) RD115 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1327_1329delTTGinsCC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.1039_1041delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761133 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.2 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
fbiC 1303969 c.1039_1041delGTTinsAC frameshift_variant&missense_variant 0.21 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.2 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 636 c.636C>G synonymous_variant 0.18 isoniazid
dnaA 705 c.705A>G synonymous_variant 0.16 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.18 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.22 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.22 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.23 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.22 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.21 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 805 c.805T>C synonymous_variant 0.24 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.26 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.26 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.27 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.25 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.23 isoniazid
dnaA 843 c.843T>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 846 c.846T>C synonymous_variant 0.23 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.23 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.17 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.17 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.18 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.19 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.18 isoniazid
dnaA 1177 p.Ala393Ser missense_variant 0.18 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.18 isoniazid
dnaA 1197 c.1197T>G synonymous_variant 0.18 isoniazid
dnaA 1204 c.1204C>T synonymous_variant 0.19 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.19 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.24 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.25 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.27 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.25 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.21 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.21 isoniazid
dnaA 1293 c.1293T>G synonymous_variant 0.21 isoniazid
dnaA 1302 c.1302C>G synonymous_variant 0.22 isoniazid
dnaA 1314 c.1314A>G synonymous_variant 0.16 isoniazid
gyrB 6214 c.975G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6217 c.978G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.19 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6274 c.1035C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6286 c.1047T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6299 c.1060C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.22 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6878 c.1639T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6904 c.-398C>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 6911 p.Asn558His missense_variant 0.28 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6925 c.-377T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6931 c.-371A>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6934 c.-368A>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 6937 c.1698G>A synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6949 c.-353A>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6955 c.-347G>A upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6967 c.-335T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6970 c.-332C>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7427 c.126G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7487 c.186C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7490 c.189C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7517 c.216G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7538 c.237G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7541 c.240C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7715 c.414G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7730 p.Arg143Ser missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7799 c.498A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8040 p.Gly247Ser missense_variant 0.92 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8090 c.789C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8174 c.873C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8234 c.933T>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8235 c.934_936delTTAinsCG frameshift_variant&missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8294 c.993T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8351 c.1050C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8442 c.1141C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8498 c.1197C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8537 c.1236G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8557 p.Ala419Asp missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 8624 c.1323G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8717 c.1416C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8720 c.1419G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8726 c.1425G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8732 c.1431G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8735 c.1434C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8747 c.1446A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8765 p.Asp488Glu missense_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8767 p.Arg489Lys missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8779 p.Asp493Ala missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8918 c.1617C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8951 c.1650G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.3 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9023 c.1722A>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9204 p.Ser635Thr missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.14 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9275 c.1974G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9278 c.1977G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9291 c.1990C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9311 c.2010C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
fgd1 491083 p.Val101Ile missense_variant 0.14 clofazimine
pretomanid
delamanid
fgd1 491091 c.309T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491094 c.312C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491106 c.324T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491137 p.Glu119Gln missense_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Glu missense_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491166 c.384G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491196 c.414A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
ccsA 620269 p.Val127Ile missense_variant 0.14 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.14 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>C synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620307 c.417C>G synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620646 c.756G>A synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620661 c.771C>G synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620703 c.813G>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620710 p.Val274Met missense_variant 0.16 capreomycin
amikacin
kanamycin
Rv0565c 657242 p.Glu77Lys missense_variant 0.17 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.19 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.2 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.22 ethionamide
Rv0565c 657267 c.204G>C synonymous_variant 0.21 ethionamide
Rv0565c 657291 c.180C>G synonymous_variant 0.21 ethionamide
Rv0565c 657300 c.171C>T synonymous_variant 0.2 ethionamide
Rv0565c 657641 c.-171C>G upstream_gene_variant 0.17 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.18 ethionamide
Rv0565c 657678 c.-209_-208delAAinsGG upstream_gene_variant 0.2 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAG upstream_gene_variant 0.18 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.18 ethionamide
Rv0565c 657719 c.-249C>G upstream_gene_variant 0.16 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.17 ethionamide
hadA 732346 c.417T>C synonymous_variant 0.16 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.2 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.22 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.22 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.2 isoniazid
nusG 734442 c.189G>A synonymous_variant 0.15 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.16 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.17 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>G synonymous_variant 0.23 rifampicin
nusG 734499 c.246G>C synonymous_variant 0.22 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.22 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
nusG 734595 c.342C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734596 c.343T>C synonymous_variant 0.2 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.16 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.16 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.16 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.23 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.24 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.24 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.24 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.23 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.27 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.22 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.16 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.19 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.18 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.19 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.22 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.22 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.22 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.22 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.23 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.25 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>G synonymous_variant 0.26 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.27 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.25 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761285 c.1479G>A synonymous_variant 0.22 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761354 c.1548C>A synonymous_variant 0.17 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.16 rifampicin
rpoB 761373 p.Val523His missense_variant 0.16 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.2 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.16 rifampicin
rpoB 761437 p.Ala544Asp missense_variant 0.16 rifampicin
rpoB 761439 p.Asp545Asn missense_variant 0.16 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.16 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.16 rifampicin
rpoB 761452 p.Val549Ala missense_variant 0.16 rifampicin
rpoB 761457 c.1651_1653delCCGinsGC frameshift_variant&missense_variant 0.16 rifampicin
rpoB 761462 c.1656C>G synonymous_variant 0.17 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.23 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.22 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.17 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.18 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761657 c.1851C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.2 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.2 rifampicin
rpoB 761714 c.1908C>G synonymous_variant 0.17 rifampicin
rpoB 761735 c.1929C>G synonymous_variant 0.17 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.18 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.18 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.19 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.18 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.19 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.22 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.2 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.21 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.2 rifampicin
rpoB 761847 p.Cys681Ser missense_variant 0.2 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.21 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.2 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761873 c.2067A>G synonymous_variant 0.21 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.2 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.18 rifampicin
rpoB 761999 c.2193G>C synonymous_variant 0.22 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.22 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.21 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.18 rifampicin Uncertain significance
rpoB 762140 c.2334G>C synonymous_variant 0.17 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.17 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>G synonymous_variant 0.19 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.17 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762347 c.2541T>C synonymous_variant 0.16 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.16 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.16 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.16 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.15 rifampicin
rpoC 762410 c.-960T>C upstream_gene_variant 0.22 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 762551 c.-819C>T upstream_gene_variant 0.13 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.29 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.31 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.25 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.22 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.21 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCC upstream_gene_variant 0.17 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763220 c.-150G>C upstream_gene_variant 0.16 rifampicin
rpoC 763402 c.33C>G synonymous_variant 0.21 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.21 rifampicin
rpoC 763441 c.72C>G synonymous_variant 0.28 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.24 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763658 c.289_291delCTTinsTG frameshift_variant&missense_variant 0.28 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.16 rifampicin
rpoC 763717 c.348T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.16 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.17 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.17 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.15 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.15 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.18 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.2 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.2 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.19 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.19 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.18 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.18 rifampicin
rpoC 763919 c.550C>T synonymous_variant 0.2 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.17 rifampicin
rpoC 763960 c.591T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763967 p.Gly200Ser missense_variant 0.17 rifampicin
rpoC 763978 c.609C>G synonymous_variant 0.19 rifampicin
rpoC 764011 c.642T>C synonymous_variant 0.15 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.18 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.19 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.2 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.2 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.19 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.19 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.24 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Gln missense_variant 0.22 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.21 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.19 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.17 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.17 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764282 c.913_915delTCGinsAGC synonymous_variant 0.16 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.19 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.2 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.23 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.24 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.27 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.16 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.19 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 765349 c.1980T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.2 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.21 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.2 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.2 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.24 rifampicin
rpoC 765452 c.2083_2085delGCCinsTG frameshift_variant&missense_variant 0.23 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765535 c.2166C>T synonymous_variant 0.18 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.18 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765578 c.2209C>T synonymous_variant 0.18 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.19 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.2 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.19 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.17 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.17 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.18 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.18 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.2 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.19 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.19 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765970 c.2601C>T synonymous_variant 0.23 rifampicin
rpoC 765979 c.2610C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765985 c.2616C>T synonymous_variant 0.21 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.18 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.18 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.2 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.19 rifampicin
rpoC 766069 c.2700G>A synonymous_variant 0.17 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.15 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.15 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.17 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.23 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.21 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.17 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.17 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.17 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766522 c.3153C>G synonymous_variant 0.2 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.19 rifampicin
rpoC 766531 c.3162G>T synonymous_variant 0.19 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.17 rifampicin
rpoC 766607 c.3238_3240delATCinsCG frameshift_variant&missense_variant 0.16 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.17 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.18 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.2 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.2 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.21 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.26 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.27 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.28 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.35 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.35 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.35 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.36 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.31 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.31 rifampicin
rpoC 766978 c.3609C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.3 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.31 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.29 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.22 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.23 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>G synonymous_variant 0.21 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775847 c.2634G>C synonymous_variant 0.18 clofazimine
bedaquiline
mmpL5 775851 p.Ser877Thr missense_variant 0.18 clofazimine
bedaquiline
mmpL5 775856 c.2625T>C synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 775864 p.Ala873Ser missense_variant 0.17 clofazimine
bedaquiline
mmpL5 775865 c.2616T>G synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 775883 c.2596_2598delATCinsTG frameshift_variant&missense_variant 0.19 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775886 c.2595A>C synonymous_variant 0.21 clofazimine
bedaquiline
mmpL5 775898 c.2583G>A synonymous_variant 0.23 clofazimine
bedaquiline
mmpL5 775901 c.2580G>A synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 775904 c.2577G>A synonymous_variant 0.18 clofazimine
bedaquiline
mmpL5 775909 p.Leu858Phe missense_variant 0.18 clofazimine
bedaquiline
mmpL5 775912 c.2569C>A synonymous_variant 0.18 clofazimine
bedaquiline
mmpL5 775916 c.2565T>G synonymous_variant 0.25 clofazimine
bedaquiline
mmpL5 775937 c.2544G>C synonymous_variant 0.18 clofazimine
bedaquiline
mmpL5 775966 p.Ala839Ser missense_variant 0.26 clofazimine
bedaquiline
mmpL5 775975 c.2506T>C synonymous_variant 0.21 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.18 clofazimine
bedaquiline
mmpL5 776009 c.2472A>G synonymous_variant 0.17 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781631 c.72G>C synonymous_variant 0.16 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.17 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.17 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.19 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.19 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.18 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.17 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.17 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.17 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.17 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.17 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.2 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.21 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.21 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.2 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.2 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.23 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.24 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.25 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.27 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.16 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.17 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.17 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.18 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.18 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.2 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.25 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.24 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.24 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.24 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.24 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.23 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.23 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.21 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.21 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.21 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.17 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.17 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.19 linezolid
rplC 800814 c.6A>G synonymous_variant 0.17 linezolid
rplC 800817 c.9A>T synonymous_variant 0.18 linezolid
rplC 800844 c.36T>C synonymous_variant 0.19 linezolid
rplC 800865 c.57A>G synonymous_variant 0.17 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.17 linezolid
rplC 801174 c.366T>C synonymous_variant 0.16 linezolid
rplC 801183 c.375C>A synonymous_variant 0.16 linezolid
rplC 801222 c.414T>C synonymous_variant 0.16 linezolid
rplC 801246 c.438C>G synonymous_variant 0.17 linezolid
rplC 801249 c.441T>G synonymous_variant 0.18 linezolid
rplC 801255 c.447C>T synonymous_variant 0.19 linezolid
rplC 801267 c.459A>C synonymous_variant 0.16 linezolid
rplC 801301 c.493C>A synonymous_variant 0.14 linezolid
fbiC 1303575 c.645G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303638 c.708A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303660 p.Val244Thr missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303674 c.744C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303701 c.771C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303716 c.786C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303881 c.951G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303911 c.981G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303923 c.993C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303929 c.999G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303973 p.Gly348Ala missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303981 p.Val351Ile missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303995 c.1065C>T synonymous_variant 0.24 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304001 c.1071C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304046 c.1116C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304523 c.1593G>T synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>A synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304545 p.Val539Ile missense_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304727 c.1797A>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304754 c.1824G>A synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304961 c.2031C>T synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1305331 p.Glu801Lys missense_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1305381 c.2451G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1305393 c.2463T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305405 c.2475A>G synonymous_variant 0.16 clofazimine Not assoc w R - Interim
pretomanid
delamanid
sigE 1364802 c.390C>A synonymous_variant 0.15 pyrazinamide
sigE 1364835 c.423C>G synonymous_variant 0.16 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.17 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 0.17 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.18 pyrazinamide
sigE 1364866 c.454_456delGCTinsTG frameshift_variant&missense_variant 0.17 pyrazinamide Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472030 n.185G>A non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>C non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473945 n.288T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.21 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1474056 n.399T>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.23 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.21 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476725 n.3068C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
inhA 1674279 c.78A>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674280 p.Arg27Lys missense_variant 0.18 ethionamide
isoniazid
inhA 1674285 c.84A>G synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674295 p.Gln32Ala missense_variant 0.18 ethionamide
isoniazid
inhA 1674300 c.99C>G synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674303 c.102C>G synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674307 c.106C>T synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674315 c.114C>G synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674321 c.120G>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674342 c.141T>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.18 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.17 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674564 c.363C>T synonymous_variant 0.2 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674582 c.381T>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.21 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674639 c.438C>T synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674994 p.His265Asn missense_variant 0.15 ethionamide
isoniazid
rpsA 1833568 c.27G>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.19 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.19 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.21 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.29 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.3 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.27 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834261 c.720A>C synonymous_variant 0.18 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.22 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.27 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.17 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.2 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.21 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.22 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834688 c.1147_1148delAGinsTC synonymous_variant 0.15 pyrazinamide
rpsA 1834836 p.Met432Thr missense_variant 0.99 pyrazinamide Not assoc w R - Interim
tsnR 1853370 c.-236G>T upstream_gene_variant 0.15 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2102009 p.Ser345Asn missense_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2102020 c.1023A>G synonymous_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2102023 c.1020G>C synonymous_variant 0.17 ethionamide
delamanid
isoniazid Not assoc w R - Interim
ndh 2102026 c.1017G>C synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2102050 c.993T>C synonymous_variant 0.16 ethionamide
delamanid
isoniazid
katG 2156196 c.-85C>T upstream_gene_variant 1.0 isoniazid Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517947 c.-168C>T upstream_gene_variant 0.27 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.18 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.18 isoniazid
kasA 2517992 c.-123C>G upstream_gene_variant 0.17 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.17 isoniazid
kasA 2518483 c.369C>G synonymous_variant 0.18 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.2 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.2 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.18 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.17 isoniazid
kasA 2518540 c.426T>G synonymous_variant 0.18 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.18 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.17 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.17 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.18 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.19 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.19 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.2 isoniazid
kasA 2518621 c.507G>A synonymous_variant 0.23 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.22 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.21 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.22 isoniazid
kasA 2518687 c.573C>T synonymous_variant 0.23 isoniazid
kasA 2518690 c.576C>T synonymous_variant 0.22 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.23 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.24 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.22 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.23 isoniazid
kasA 2518717 c.603C>T synonymous_variant 0.25 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.23 isoniazid
kasA 2518741 c.627G>C synonymous_variant 0.24 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.24 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.2 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.21 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.19 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.19 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.19 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.2 isoniazid
kasA 2518855 c.741C>G synonymous_variant 0.17 isoniazid
kasA 2518919 p.Gly269Ser missense_variant 0.92 isoniazid
folC 2746340 p.Ala420Val missense_variant 1.0 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.2 para-aminosalicylic_acid
folC 2747359 c.240C>G synonymous_variant 0.2 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.2 para-aminosalicylic_acid
Rv2477c 2782981 c.1062G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.28 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783059 c.984T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783110 c.933C>A synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>T synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783320 c.723C>T synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783365 c.678C>T synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783373 p.Glu224Gln missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783512 c.531A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783629 c.414C>T synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783700 p.Thr115Ser missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783794 c.249G>A synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 p.Asp61Glu missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783920 c.123G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784405 c.-363T>C upstream_gene_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3064962 c.1230C>A synonymous_variant 0.14 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064973 p.Ala407Ser missense_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064974 c.1218T>C synonymous_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064980 c.1212C>A synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064995 c.1197C>G synonymous_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064998 c.1194A>G synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065018 p.Asn392His missense_variant 0.53 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065028 c.1164G>C synonymous_variant 0.67 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065031 c.1161G>C synonymous_variant 0.72 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065039 c.1070_1152delNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNT frameshift_variant 1.0 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065040 c.1152C>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065048 c.1144C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065064 c.1128G>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065979 c.213T>C synonymous_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065993 p.Val67Ile missense_variant 0.16 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065994 c.198T>C synonymous_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065997 c.195C>G synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066002 p.Met64Leu missense_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066024 c.168T>C synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066040 p.Gly51Thr missense_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066042 c.150T>C synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066050 p.Leu48Met missense_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066087 c.105A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
thyX 3067391 c.555G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067412 c.534C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067470 p.Asn159Ser missense_variant 0.16 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067500 p.Lys149Arg missense_variant 0.23 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.24 para-aminosalicylic_acid
thyX 3067526 c.420C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.27 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.27 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.22 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.2 para-aminosalicylic_acid
thyX 3067559 p.Arg129Gln missense_variant 0.18 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.17 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.18 para-aminosalicylic_acid
thyX 3067571 c.375C>T synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067577 p.Glu123Asp missense_variant 0.17 para-aminosalicylic_acid
thyX 3067582 p.Met122Leu missense_variant 0.17 para-aminosalicylic_acid
thyX 3067586 c.360C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067601 c.345G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067604 c.342G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067613 c.333G>A synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067640 c.306G>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067643 c.303C>T synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067724 c.222G>A synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067742 c.204A>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067762 c.184C>A synonymous_variant 0.14 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.14 para-aminosalicylic_acid
thyX 3067787 c.159G>A synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067826 c.120C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073868 p.Thr202Ala missense_variant 0.83 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.17 para-aminosalicylic_acid
thyA 3073878 c.594G>A synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073926 c.546G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074010 c.462C>A synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.23 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074082 c.390G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074100 c.372T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074117 c.355C>T synonymous_variant 0.17 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
lpqB 3624401 c.510C>T synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624464 c.447A>G synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624470 c.441T>C synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624476 c.435C>G synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624482 c.429T>C synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624485 p.Asp142Gly missense_variant 0.17 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624512 c.399C>G synonymous_variant 0.15 bedaquiline
rifampicin
lpqB 3624713 c.198C>T synonymous_variant 0.15 bedaquiline
rifampicin
lpqB 3624728 c.183C>T synonymous_variant 0.16 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625572 p.Thr348Ser missense_variant 0.16 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.22 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.26 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625627 c.-717C>T upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625648 c.-738T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625656 c.958T>C synonymous_variant 0.28 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.29 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625735 c.879C>A synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625750 c.864G>A synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.25 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 c.852A>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.28 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625840 c.-930A>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3626723 c.627C>T synonymous_variant 0.14 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626759 c.591T>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.19 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3626912 c.438T>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626930 c.-317A>T upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3627215 c.135G>A synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.16 bedaquiline
rifampicin
rpoA 3877542 c.966C>T synonymous_variant 0.16 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.16 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.23 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.21 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.17 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877743 c.765T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.31 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.3 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.26 rifampicin
rpoA 3877899 p.Ser203Thr missense_variant 0.22 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.21 rifampicin
rpoA 3877953 c.555G>A synonymous_variant 0.24 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.17 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.18 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.18 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.18 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.18 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.2 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.2 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.2 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.21 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.19 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.18 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.2 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.19 rifampicin
rpoA 3878100 c.408C>G synonymous_variant 0.21 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.21 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.23 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.26 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.23 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Glu missense_variant 0.23 rifampicin
rpoA 3878169 c.339G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.24 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.22 rifampicin
rpoA 3878202 c.306G>C synonymous_variant 0.21 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878220 c.288C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.19 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.18 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.17 rifampicin
rpoA 3878364 c.144A>G synonymous_variant 0.18 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.18 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.19 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.22 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.22 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.22 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.21 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.18 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.18 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.17 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.15 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.19 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.16 rifampicin
rpoA 3878781 c.-274A>G upstream_gene_variant 0.16 rifampicin
rpoA 3878782 c.-275G>C upstream_gene_variant 0.16 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.16 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3878806 c.-299C>A upstream_gene_variant 0.16 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.16 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.15 rifampicin
rpoA 3878989 c.-482G>C upstream_gene_variant 0.16 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.21 rifampicin
rpoA 3879040 c.-533G>C upstream_gene_variant 0.21 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.21 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.21 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.19 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.22 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.23 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.21 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.22 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.21 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.18 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.16 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.16 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.16 rifampicin
clpC1 4038287 c.2418C>T synonymous_variant 0.85 pyrazinamide Not assoc w R
clpC1 4038293 c.2412G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.17 pyrazinamide
clpC1 4038308 c.2395_2397delGTGinsAC frameshift_variant&missense_variant 0.16 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.16 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038461 p.Ala748Asp missense_variant 0.17 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.2 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.23 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.15 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.18 pyrazinamide
clpC1 4038851 c.1854G>A synonymous_variant 0.22 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.24 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.22 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039127 c.1578G>A synonymous_variant 0.17 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039484 c.1221T>G synonymous_variant 0.19 pyrazinamide
clpC1 4039493 c.1212C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039517 c.1188C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039524 p.Phe394Tyr missense_variant 0.21 pyrazinamide
clpC1 4039526 c.1179G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039532 c.1173C>T synonymous_variant 0.26 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.25 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.18 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.17 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040354 c.351A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.18 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.19 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.16 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040431 c.274T>C synonymous_variant 0.19 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040528 c.177G>C synonymous_variant 0.16 pyrazinamide
glpK 4138502 c.1254T>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138511 c.1245C>T synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138514 c.1242A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138518 p.Glu413Ala missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138523 c.1233C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138535 c.1221T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138538 c.1218C>T synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138547 c.1209C>T synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138568 c.1188A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138571 c.1185C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138583 c.1173G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138586 c.1170C>T synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138631 c.1125C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>T synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138664 c.1092G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138667 c.1089G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138670 c.1086G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.22 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138695 p.Pro354Asp missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138703 c.1053C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138706 c.1050C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138714 p.Ala348Ser missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138715 c.1041G>A synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139165 c.591A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139168 c.588T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139175 p.Val194Ala missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139540 p.Ile72Met missense_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139552 c.202_204delGCGinsTC frameshift_variant&missense_variant 0.18 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139575 p.Val61Ile missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139581 p.Asn59Asp missense_variant 0.22 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139588 c.168G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139597 c.159C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139630 c.126C>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139651 p.His35Gln missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240632 p.Met257Thr missense_variant 0.18 ethambutol
embC 4240642 c.780G>C synonymous_variant 0.18 ethambutol
embC 4240645 c.783G>C synonymous_variant 0.17 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.17 ethambutol Not assoc w R
embC 4240706 p.Val282Met missense_variant 0.14 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4240783 c.921G>C synonymous_variant 0.28 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.24 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.23 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.23 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.16 ethambutol
embC 4240945 c.1083T>C synonymous_variant 0.15 ethambutol
embC 4240966 c.1104G>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4240980 p.Thr373Lys missense_variant 0.15 ethambutol
embC 4240990 c.1128A>G synonymous_variant 0.17 ethambutol
embC 4240996 c.1134G>C synonymous_variant 0.19 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.21 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.22 ethambutol
embC 4241026 c.1164C>G synonymous_variant 0.23 ethambutol
embC 4241035 c.1173G>A synonymous_variant 0.22 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.22 ethambutol
embC 4241086 c.1224G>C synonymous_variant 0.19 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.17 ethambutol
embC 4241141 p.Ile427Val missense_variant 0.16 ethambutol Uncertain significance
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245089 c.1857G>C synonymous_variant 0.17 ethambutol
embA 4245092 c.1860C>G synonymous_variant 0.16 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.19 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.19 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.18 ethambutol
embA 4245194 c.1962G>C synonymous_variant 0.16 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.16 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.15 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.16 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.17 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.2 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.18 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.17 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.17 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.16 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.14 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.15 ethambutol Uncertain significance
embB 4248055 c.1542G>A synonymous_variant 0.14 ethambutol Not assoc w R - Interim
embB 4248085 c.1572T>C synonymous_variant 0.17 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.18 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4248206 c.1693_1695delAGCinsGG frameshift_variant&missense_variant 0.21 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.2 ethambutol
embB 4248265 c.1752C>T synonymous_variant 0.22 ethambutol
embB 4248266 c.1753C>T synonymous_variant 0.22 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.23 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.17 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.15 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.15 ethambutol Uncertain significance
ubiA 4269149 p.Val229Leu missense_variant 0.16 ethambutol Uncertain significance
aftB 4269183 c.-347T>C upstream_gene_variant 0.18 ethambutol
aftB 4269201 c.-365A>G upstream_gene_variant 0.21 ethambutol
ubiA 4269209 p.Ser209Ala missense_variant 0.21 ethambutol
ubiA 4269220 p.Ala205Lys missense_variant 0.2 ethambutol
ubiA 4269222 c.612T>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
aftB 4269225 c.-389C>G upstream_gene_variant 0.2 ethambutol
aftB 4269231 c.-395C>G upstream_gene_variant 0.21 ethambutol
aftB 4269234 c.-398A>G upstream_gene_variant 0.22 ethambutol
ubiA 4269243 p.His197Gln missense_variant 0.21 ethambutol
ubiA 4269271 p.Val188Ala missense_variant 0.16 ethambutol Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R