TB-Profiler result

Run: ERR5979775
Summary

Run ID: ERR5979775

Sample name:

Date: 2024-04-16T00:17:11.644089

Number of reads: 7455875

Percentage reads mapped: 99.71

Median coverage: 238.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
mshA 576108 p.Ala254Gly missense_variant 0.23 ethionamide
isoniazid
mmpR5 779137 p.Arg50Trp missense_variant 0.36 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpR5 779354 p.Leu122Pro missense_variant 0.15 clofazimine
bedaquiline Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rpoA 3878637 c.-130G>C upstream_gene_variant 0.21 rifampicin