TB-Profiler result

Run: ERR7801245
Summary

Run ID: ERR7801245

Sample name:

Date: 02-04-2023 06:00:16

Number of reads: 1140733

Percentage reads mapped: 99.69

Strain: lineage4.6.1.2

Drug-resistance: HR-TB

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.6 Euro-American T;LAM None 1.0
lineage4.6.1 Euro-American (Uganda) T2 RD724 1.0
lineage4.6.1.2 Euro-American T2 RD724 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
katG 2155790 c.321delG frameshift_variant 0.2 isoniazid
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7539 p.Thr80Ala missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
embR 1416410 p.Leu313Arg missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1473470 n.-188A>G upstream_gene_variant 0.13
rrl 1474240 n.583G>T non_coding_transcript_exon_variant 0.12
rrl 1474573 n.916C>A non_coding_transcript_exon_variant 0.15
rrl 1475246 n.1589C>A non_coding_transcript_exon_variant 0.13
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2101786 c.1257G>A synonymous_variant 1.0
katG 2156243 c.-132A>G upstream_gene_variant 1.0
PPE35 2168995 p.Pro540Thr missense_variant 0.2
Rv1979c 2222484 c.681C>A synonymous_variant 0.13
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289885 c.-644C>A upstream_gene_variant 0.17
Rv2752c 3065954 p.Thr80Ala missense_variant 1.0
Rv2752c 3065962 p.Leu77Pro missense_variant 0.12
ald 3086936 c.117C>T synonymous_variant 0.12
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4245055 p.Thr608Asn missense_variant 0.97
aftB 4267975 p.Ser288Thr missense_variant 0.11
aftB 4269402 c.-566T>C upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0