TB-Profiler result

Run: ERR8158008
Summary

Run ID: ERR8158008

Sample name:

Date: 02-04-2023 07:20:20

Number of reads: 1354956

Percentage reads mapped: 99.84

Strain: lineage2.2.1

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 1.0
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 1.0
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
pncA 2289180 p.Val21Ala missense_variant 0.12 pyrazinamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7728 c.430delG frameshift_variant 0.11
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoB 762520 p.Thr905Ile missense_variant 0.17
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 764428 c.1059G>C synonymous_variant 0.11
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 777472 p.Val337Met missense_variant 1.0
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781912 p.Gly118Val missense_variant 0.18
Rv1258c 1406760 c.580_581insC frameshift_variant 0.99
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472057 n.215delT non_coding_transcript_exon_variant 0.22
rrs 1473355 n.1510G>T non_coding_transcript_exon_variant 0.33
rrl 1473586 n.-72G>T upstream_gene_variant 0.25
rrl 1473598 n.-60A>G upstream_gene_variant 0.25
rpsA 1834177 c.636A>C synonymous_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2168748 c.1850_1864delCACCCCAAATAAGTA disruptive_inframe_deletion 1.0
Rv1979c 2222136 p.Lys343Asn missense_variant 0.29
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289098 p.Lys48Asn missense_variant 0.15
thyX 3067273 c.672delC frameshift_variant 0.1
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474060 c.54C>A synonymous_variant 0.14
fprA 3474999 c.993G>A synonymous_variant 0.12
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
rpoA 3877626 c.882C>A synonymous_variant 0.12
rpoA 3878099 p.Glu137Lys missense_variant 0.22
rpoA 3878470 c.36_37delCG frameshift_variant 0.18
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
aftB 4267647 p.Asp397Gly missense_variant 1.0
aftB 4269438 c.-602C>A upstream_gene_variant 0.11
ubiA 4269478 p.Met119Thr missense_variant 0.1
ethA 4326676 p.Ser266Arg missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 1.0