TB-Profiler result

Run: ERR8774136
Summary

Run ID: ERR8774136

Sample name:

Date: 02-04-2023 08:24:07

Number of reads: 745197

Percentage reads mapped: 99.64

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7329 p.Asp10Tyr missense_variant 0.12
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 9184 p.Arg628Leu missense_variant 1.0
fgd1 491226 c.444C>T synonymous_variant 0.17
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777864 p.Val206Glu missense_variant 0.15
mmpS5 778828 p.Gln26His missense_variant 0.33
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781492 c.-68G>A upstream_gene_variant 0.12
Rv1258c 1406520 p.Gly274Val missense_variant 0.12
Rv1258c 1406854 c.487T>C synonymous_variant 0.12
embR 1416272 p.Ser359Tyr missense_variant 0.4
embR 1416534 c.813delC frameshift_variant 0.22
atpE 1461158 c.114T>C synonymous_variant 0.4
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1471674 n.-172G>T upstream_gene_variant 0.5
rrl 1475308 n.1651C>A non_coding_transcript_exon_variant 0.33
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2101863 p.Leu394Met missense_variant 0.12
PPE35 2170048 p.Leu189Val missense_variant 0.2
PPE35 2170053 p.Thr187Ser missense_variant 0.2
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2519207 p.Gly365Cys missense_variant 0.12
eis 2715469 c.-137T>C upstream_gene_variant 0.11
eis 2715473 c.-141A>G upstream_gene_variant 0.11
Rv3083 3448497 c.-7T>A upstream_gene_variant 1.0
fbiA 3640808 c.266_267insAGC disruptive_inframe_insertion 0.12
fbiA 3640812 p.Gln90His missense_variant 0.13
fbiA 3640813 p.Glu91Gln missense_variant 0.13
fbiA 3640816 p.Leu92Phe missense_variant 0.13
fbiA 3640819 p.Val93Leu missense_variant 0.13
fbiA 3640822 c.281_283delGCT disruptive_inframe_deletion 0.13
alr 3840764 c.657G>C synonymous_variant 1.0
rpoA 3878039 p.Ala157Ser missense_variant 0.13
panD 4043885 p.Asp133His missense_variant 0.11
panD 4044170 p.Leu38Met missense_variant 0.17
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4248476 p.Pro655Thr missense_variant 0.14
aftB 4268863 c.-27G>A upstream_gene_variant 0.15
ubiA 4269082 p.Ser251Trp missense_variant 0.11
ethR 4327743 p.Phe65Leu missense_variant 0.13
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0