TB-Profiler result

Run: ERR8774327
Summary

Run ID: ERR8774327

Sample name:

Date: 02-04-2023 08:26:56

Number of reads: 442106

Percentage reads mapped: 99.46

Strain: lineage4.6.1

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.6.1 Euro-American (Uganda) T2 RD724 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5077 c.-163_-162insC upstream_gene_variant 1.0
gyrB 6151 c.912C>T synonymous_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7539 p.Thr80Ala missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 490817 p.Ala12Asp missense_variant 0.33
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406189 c.1152A>G synonymous_variant 1.0
Rv1258c 1407057 p.Gly95Glu missense_variant 0.13
embR 1416294 p.Val352Leu missense_variant 0.18
embR 1416410 p.Leu313Arg missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
inhA 1674465 c.264C>T synonymous_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2153937 c.2175C>A synonymous_variant 0.4
PPE35 2170048 p.Leu189Val missense_variant 0.58
PPE35 2170053 p.Thr187Ser missense_variant 0.58
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
folC 2746660 c.938delT frameshift_variant 0.25
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
alr 3840245 c.1176C>A synonymous_variant 0.18
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4245055 p.Thr608Asn missense_variant 1.0
embB 4246555 c.42G>C synonymous_variant 0.67
embB 4246556 p.Ala15Pro missense_variant 0.67
whiB6 4338635 c.-114A>C upstream_gene_variant 1.0