TB-Profiler result

Run: ERR9027238
Summary

Run ID: ERR9027238

Sample name:

Date: 02-04-2023 09:19:21

Number of reads: 2251366

Percentage reads mapped: 99.72

Strain: lineage4.7

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.7 Euro-American (mainly T) T1;T5 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2288841 p.Ala134Val missense_variant 1.0 pyrazinamide
embB 4247429 p.Met306Val missense_variant 1.0 ethambutol
gid 4407851 c.351delG frameshift_variant 1.0 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6798 p.Gly520Ala missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
mshA 575578 c.231G>C synonymous_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.24
rpoC 764817 p.Val483Gly missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 0.99
rrl 1474294 n.637C>G non_coding_transcript_exon_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2170065 p.Ala183Gly missense_variant 0.24
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246584 p.Arg24Pro missense_variant 0.27
embB 4249732 c.3219C>G synonymous_variant 1.0
aftB 4267992 p.Thr282Met missense_variant 0.98
aftB 4268617 p.Gly74Cys missense_variant 0.2
ethA 4326929 p.Gly182Asp missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0