TB-Profiler result

Run: ERR9117805
Summary

Run ID: ERR9117805

Sample name:

Date: 2024-04-15T19:14:15.475191

Number of reads: 868431

Percentage reads mapped: 49.91

Median coverage: 26.0

Strain: lineage4.3.2

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 0.75
lineage4.3.2 Euro-American (LAM) None 0.94
lineage4 Euro-American None 0.97
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.799C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.301_303delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491083 c.301_303delGTTinsAC frameshift_variant&missense_variant 0.26 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.18 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 645 c.645A>C synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 649 c.649C>T synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 654 c.654A>G synonymous_variant 0.22 isoniazid
dnaA 660 c.660G>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>C synonymous_variant 0.25 isoniazid
dnaA 669 c.669C>T synonymous_variant 0.27 isoniazid
dnaA 672 c.672T>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 678 c.678A>G synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 681 c.681G>C synonymous_variant 0.27 isoniazid
dnaA 693 c.693A>G synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 705 c.705A>G synonymous_variant 0.23 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.23 isoniazid
dnaA 720 c.720G>A synonymous_variant 0.22 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.18 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.19 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.24 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.24 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.21 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.22 isoniazid
dnaA 876 c.876C>G synonymous_variant 0.18 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.18 isoniazid
dnaA 882 c.882C>T synonymous_variant 0.19 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.22 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.19 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.21 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.2 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 942 c.942C>G synonymous_variant 0.23 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.23 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.23 isoniazid
dnaA 960 c.960C>A synonymous_variant 0.22 isoniazid
dnaA 963 c.963C>G synonymous_variant 0.23 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.23 isoniazid
dnaA 969 c.969G>A synonymous_variant 0.23 isoniazid
dnaA 975 c.975G>T synonymous_variant 0.23 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 993 c.993A>G synonymous_variant 0.25 isoniazid
dnaA 996 c.996A>G synonymous_variant 0.28 isoniazid
dnaA 999 c.999C>G synonymous_variant 0.28 isoniazid
dnaA 1003 c.1003C>T synonymous_variant 0.27 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.28 isoniazid Not assoc w R - Interim
dnaA 1014 c.1014C>G synonymous_variant 0.28 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.32 isoniazid
dnaA 1038 c.1038A>T synonymous_variant 0.3 isoniazid
dnaA 1041 c.1041G>A synonymous_variant 0.32 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.32 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.33 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.38 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.37 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.36 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.39 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.38 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.42 isoniazid
dnaA 1129 p.Ile377Leu missense_variant 0.59 isoniazid Uncertain significance
dnaA 1137 c.1137C>G synonymous_variant 0.41 isoniazid
dnaA 1143 c.1143G>C synonymous_variant 0.34 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.39 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.39 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.4 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.43 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.41 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.39 isoniazid
dnaA 1188 c.1188G>A synonymous_variant 0.35 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.33 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.28 isoniazid
dnaA 1236 c.1236C>T synonymous_variant 0.27 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.26 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.26 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.26 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.21 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.2 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.2 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.2 isoniazid
dnaA 1299 c.1299G>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 1311 c.1311C>G synonymous_variant 0.19 isoniazid
dnaA 1317 c.1317A>G synonymous_variant 0.19 isoniazid
dnaA 1320 c.1320G>C synonymous_variant 0.2 isoniazid
dnaA 1323 c.1323C>T synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 1332 c.1332A>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 1338 c.1338T>C synonymous_variant 0.23 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.25 isoniazid
gyrB 6238 c.999G>A synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.26 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6265 c.1026C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6268 c.1029C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.42 levofloxacin Uncertain significance
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 6949 c.-353A>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 7099 c.-203G>A upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7406 c.105G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.44 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7532 c.231T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7562 c.261C>T synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7571 c.270G>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCC frameshift_variant&missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7697 c.396C>A synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7710 c.409_411delTTGinsCC frameshift_variant&missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7721 c.420G>A synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7725 c.424C>T synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7728 c.427_429delAGGinsCT frameshift_variant&missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7796 c.495G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8111 c.810G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8247 c.946_948delATCinsGG frameshift_variant&missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8294 c.993T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8337 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.42 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>T synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8367 c.1066C>T synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8372 c.1071G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.36 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8400 c.1099_1101delGACinsAT frameshift_variant&missense_variant 0.36 levofloxacin
moxifloxacin
gyrA 8417 c.1116C>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8531 c.1230G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8553 c.1252C>A synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8780 p.Asp493Glu missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8807 c.1506C>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8808 c.1507_1509delGGAinsCG frameshift_variant&missense_variant 0.64 levofloxacin
moxifloxacin
gyrA 8816 c.1515C>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.43 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.43 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>A synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.33 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>A synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.43 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9153 p.Thr618Glu missense_variant 0.36 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.42 levofloxacin
moxifloxacin
gyrA 9218 c.1917C>T synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9227 c.1926C>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 9293 c.1992G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9308 c.2007C>T synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9312 c.2011C>T synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9317 c.2016G>T synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
fgd1 491043 c.261T>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491063 p.Gly94Ala missense_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491077 p.Asn99Asp missense_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491082 c.300T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491091 c.309T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491094 c.312C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491097 c.315G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491100 c.318C>T synonymous_variant 0.26 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491106 c.324T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491130 c.348C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Asp missense_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491151 c.369G>A synonymous_variant 0.3 clofazimine
pretomanid
delamanid
mshA 575719 c.372C>T synonymous_variant 0.33 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.44 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.44 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.46 ethionamide
isoniazid
mshA 575752 c.405G>C synonymous_variant 0.42 ethionamide
isoniazid
mshA 575755 c.408G>A synonymous_variant 0.4 ethionamide
isoniazid
mshA 575756 c.409C>T synonymous_variant 0.42 ethionamide
isoniazid
mshA 575770 c.423G>A synonymous_variant 0.46 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.43 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.41 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.41 ethionamide
isoniazid
mshA 575809 c.462C>T synonymous_variant 0.46 ethionamide
isoniazid
mshA 575812 c.465C>T synonymous_variant 0.46 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.5 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.47 ethionamide
isoniazid
mshA 575830 c.483C>G synonymous_variant 0.47 ethionamide
isoniazid
mshA 575833 c.486C>G synonymous_variant 0.47 ethionamide
isoniazid
mshA 575845 c.498C>T synonymous_variant 0.45 ethionamide
isoniazid Not assoc w R - Interim
mshA 575884 c.537G>C synonymous_variant 0.4 ethionamide
isoniazid
mshA 575887 c.540G>C synonymous_variant 0.39 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.34 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.33 ethionamide
isoniazid
mshA 575908 c.561A>G synonymous_variant 0.28 ethionamide
isoniazid
mshA 575917 p.Asp190Glu missense_variant 0.28 ethionamide
isoniazid
mshA 575920 c.573C>G synonymous_variant 0.25 ethionamide
isoniazid
mshA 575924 p.Gly193Ser missense_variant 0.26 ethionamide
isoniazid
ccsA 619555 c.-336C>G upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619561 c.-330G>C upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 619570 c.-321G>C upstream_gene_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 619574 c.-317G>A upstream_gene_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 619584 c.-307A>T upstream_gene_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 619609 c.-282G>T upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620226 c.336G>A synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620245 c.355T>C synonymous_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620249 p.Ser120Cys missense_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620254 c.364_366delCTCinsTG frameshift_variant&missense_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620265 c.375C>G synonymous_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620268 c.378G>C synonymous_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>C synonymous_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620284 c.394_396delGCGinsCC frameshift_variant&missense_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.42 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>T synonymous_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620310 c.420C>T synonymous_variant 0.42 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620346 c.456C>G synonymous_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.45 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620376 c.486G>C synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620389 c.499C>T synonymous_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.36 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620421 c.531G>C synonymous_variant 0.38 capreomycin
amikacin
kanamycin
Rv0565c 656289 c.1182C>G synonymous_variant 0.22 ethionamide
Rv0565c 657578 c.-108T>C upstream_gene_variant 0.41 ethionamide
Rv0565c 657592 c.-122A>C upstream_gene_variant 0.38 ethionamide
Rv0565c 657600 c.-132_-131delCA upstream_gene_variant 0.41 ethionamide
Rv0565c 657606 c.-136T>G upstream_gene_variant 0.36 ethionamide
Rv0565c 657607 c.-138_-137insCA upstream_gene_variant 0.36 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.28 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.26 ethionamide
Rv0565c 657678 c.-209_-208delAAinsTC upstream_gene_variant 0.26 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.24 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.22 ethionamide
hadA 731708 c.-222G>C upstream_gene_variant 0.24 isoniazid
hadA 731710 c.-220A>T upstream_gene_variant 0.24 isoniazid
hadA 731711 c.-219T>C upstream_gene_variant 0.24 isoniazid
hadA 731717 c.-213T>G upstream_gene_variant 0.31 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 0.35 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.38 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.32 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.33 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.35 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.3 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.28 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.36 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.39 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.43 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.52 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.61 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.62 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.45 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.46 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.46 isoniazid
nusG 734442 c.189G>A synonymous_variant 0.26 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.26 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.26 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.26 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.24 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.26 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.27 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.24 rifampicin
nusG 734601 c.348C>G synonymous_variant 0.26 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.29 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.43 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.38 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.36 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.39 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.42 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.35 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.39 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.38 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.39 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.38 rifampicin
rpoB 760430 c.624T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.32 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.3 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.27 rifampicin Uncertain significance
rpoB 760611 c.805T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>T synonymous_variant 0.19 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.18 rifampicin
rpoB 761057 c.1251G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.42 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.42 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.47 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.49 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.26 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.26 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.28 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.31 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.33 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.32 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.32 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761747 c.1941G>C synonymous_variant 0.45 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.47 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.44 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.38 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.39 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.38 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.33 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.33 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.3 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.34 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.39 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.37 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.42 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.48 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.34 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.32 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.33 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.32 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.32 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.33 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.32 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.33 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.36 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.3 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.24 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.22 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.21 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.25 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.44 rifampicin Uncertain significance
rpoB 762788 c.2982G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762789 p.Leu995Met missense_variant 0.44 rifampicin Uncertain significance
rpoC 762794 c.-576C>G upstream_gene_variant 0.47 rifampicin
rpoB 762799 p.Ala998Gly missense_variant 0.45 rifampicin Uncertain significance
rpoB 762810 c.3004_3006delGCCinsTG frameshift_variant&missense_variant 0.41 rifampicin
rpoB 762813 p.Met1003Val missense_variant 0.43 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762926 c.3120C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.33 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.28 rifampicin
rpoC 763025 c.-345C>T upstream_gene_variant 0.26 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.35 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.38 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.33 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.39 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.5 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.23 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.24 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.24 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.28 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.28 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.42 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.38 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.32 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764206 c.837T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.36 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.29 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.26 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.27 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.29 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.29 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.35 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.34 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.35 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.45 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.47 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.47 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.47 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.44 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.39 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.39 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.45 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.27 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.27 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.29 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.28 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.24 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.22 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.39 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.43 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.43 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.42 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.46 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.43 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.4 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.33 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.36 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.34 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.38 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.35 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.44 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.5 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.48 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.46 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.38 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.34 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.33 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.19 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766142 c.2773C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766280 p.Ser971Gly missense_variant 0.17 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.22 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.27 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.26 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.31 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.37 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.41 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.41 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.4 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.39 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.36 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.33 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.29 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.25 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.26 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.26 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.29 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.27 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.26 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.26 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.25 rifampicin
rpoC 766549 c.3180G>T synonymous_variant 0.25 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.38 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.33 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.33 rifampicin
rpoC 766660 c.3291G>C synonymous_variant 0.34 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.29 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.29 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.27 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.26 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.42 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.42 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.35 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.34 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.28 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781649 c.90T>C synonymous_variant 0.37 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.41 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.56 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.56 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.62 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.65 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.64 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.64 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.6 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.57 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.57 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.53 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.29 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.31 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.26 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.24 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.24 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.19 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.22 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.28 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.35 streptomycin Uncertain significance
rplC 800582 c.-227C>G upstream_gene_variant 0.3 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.26 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.27 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.38 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.44 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.39 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.34 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.33 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.37 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.36 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.37 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.33 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.33 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.26 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.25 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.26 linezolid
rplC 800814 c.6A>G synonymous_variant 0.27 linezolid
rplC 800817 c.9A>T synonymous_variant 0.25 linezolid
rplC 801438 c.630T>C synonymous_variant 0.18 linezolid
rplC 801442 p.Ile212Val missense_variant 0.18 linezolid
fbiC 1303575 c.645G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303797 c.867A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304553 c.1623C>T synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.32 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304739 c.1809C>T synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.53 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fbiC 1304862 c.1932G>A synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
atpE 1460861 c.-184C>G upstream_gene_variant 0.2 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.38 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472496 n.651T>A non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472597 n.752G>A non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1474558 n.901G>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1474584 n.927C>T non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.64 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.86 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.91 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474883 n.1226T>C non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475869 n.2212C>A non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475963 n.2306G>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.8 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476225 n.2568T>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476227 n.2570C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid Uncertain significance
rrl 1476229 n.2572C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.83 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476293 n.2636C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476294 n.2637A>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476302 n.2645G>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476313 n.2656G>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476338 n.2681C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.86 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.42 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.74 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.61 capreomycin Not assoc w R
linezolid Uncertain significance
inhA 1674672 c.471C>G synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674738 c.537C>G synonymous_variant 0.2 ethionamide
isoniazid
rpsA 1833554 p.Thr5Ala missense_variant 0.2 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.25 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.28 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.37 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.38 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.39 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.4 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.4 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.43 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.4 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.41 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.39 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.43 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.42 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.36 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834081 c.540C>T synonymous_variant 0.29 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.21 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.22 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.37 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.43 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.45 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.38 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.31 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.26 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.28 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.29 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.3 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.28 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1918036 p.Arg33Ser missense_variant 0.6 capreomycin
bacA 2064978 c.-250G>C upstream_gene_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517950 c.-165C>G upstream_gene_variant 0.25 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.23 isoniazid
kasA 2518540 c.426T>C synonymous_variant 0.28 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.42 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.42 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.42 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.43 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.45 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.41 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.41 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.58 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.6 isoniazid
kasA 2518639 c.525G>C synonymous_variant 0.56 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.41 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.33 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.35 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.33 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.31 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.31 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.32 isoniazid
kasA 2518921 c.807T>C synonymous_variant 0.31 isoniazid
kasA 2518927 c.813C>G synonymous_variant 0.3 isoniazid
kasA 2518936 c.822C>G synonymous_variant 0.31 isoniazid
kasA 2518939 c.825T>C synonymous_variant 0.31 isoniazid
kasA 2518942 c.828T>C synonymous_variant 0.33 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.31 isoniazid
ahpC 2726601 p.Ile137Leu missense_variant 0.32 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.34 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.29 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.29 isoniazid
Rv2477c 2782864 c.1179T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782869 p.Ala392Thr missense_variant 0.35 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782876 c.1167G>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.4 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.38 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.34 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783146 c.897G>A synonymous_variant 0.41 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin
amikacin Not assoc w R - Interim
Rv2477c 2783149 c.894G>C synonymous_variant 0.41 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.41 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783293 c.750G>A synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783329 c.714G>A synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783344 c.699C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
thyX 3067530 p.Ala139Ser missense_variant 0.53 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.6 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.55 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.5 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.54 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.62 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.62 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.64 para-aminosalicylic_acid
thyX 3067583 c.363C>G synonymous_variant 0.67 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.6 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.57 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.55 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.55 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.57 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.58 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.55 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067691 c.253_255delATCinsCG frameshift_variant&missense_variant 0.44 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.42 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.43 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.43 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.39 para-aminosalicylic_acid
thyX 3067736 c.208_210delTTCinsCT frameshift_variant&missense_variant 0.4 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.4 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.44 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.43 para-aminosalicylic_acid
thyX 3067772 c.174C>G synonymous_variant 0.43 para-aminosalicylic_acid
thyX 3067781 c.165C>A synonymous_variant 0.43 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.46 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.44 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.42 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.26 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067898 p.Asp16Glu missense_variant 0.27 para-aminosalicylic_acid
thyA 3073860 c.612C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3073866 c.604_606delACCinsGG frameshift_variant&missense_variant 0.29 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.28 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.4 para-aminosalicylic_acid
thyA 3073898 p.Ala192Ser missense_variant 0.4 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.41 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.45 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.44 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.44 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.42 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.44 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.42 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.27 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
lpqB 3623492 c.1419T>C synonymous_variant 0.29 bedaquiline
rifampicin
lpqB 3623512 p.Gly467Ser missense_variant 0.32 bedaquiline
rifampicin
lpqB 3623528 c.1383G>C synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3623549 c.1362C>G synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3623555 c.1354_1356delGGGinsAC frameshift_variant&missense_variant 0.26 bedaquiline
rifampicin Uncertain significance
lpqB 3623561 c.1350T>C synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3623570 c.1341A>G synonymous_variant 0.25 bedaquiline
rifampicin
lpqB 3623573 c.1336_1338delCTTinsTG frameshift_variant&synonymous_variant 0.25 bedaquiline
rifampicin Uncertain significance
lpqB 3623580 p.Asn444Thr missense_variant 0.26 bedaquiline
rifampicin
lpqB 3623587 p.Ala442Pro missense_variant 0.27 bedaquiline
rifampicin
lpqB 3623597 c.1314C>G synonymous_variant 0.28 bedaquiline
rifampicin
lpqB 3623601 p.Ser437Thr missense_variant 0.28 bedaquiline
rifampicin
lpqB 3623612 p.Thr433Val missense_variant 0.28 bedaquiline
rifampicin
lpqB 3623630 c.1281G>C synonymous_variant 0.28 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625510 c.-600T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
lpqB 3625513 c.-603G>C upstream_gene_variant 0.29 bedaquiline
rifampicin
lpqB 3625518 c.-608T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
lpqB 3625525 c.-615G>C upstream_gene_variant 0.29 bedaquiline
rifampicin
lpqB 3625528 c.-618G>T upstream_gene_variant 0.31 bedaquiline
rifampicin
lpqB 3625537 c.-627T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
lpqB 3625543 c.-633G>C upstream_gene_variant 0.34 bedaquiline
rifampicin
lpqB 3625549 c.-639G>A upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.38 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.38 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.46 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.44 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.48 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.47 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.38 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.35 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.35 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.31 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.37 bedaquiline
rifampicin
lpqB 3625749 c.-839C>T upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3625750 c.864G>A synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.38 bedaquiline
rifampicin Uncertain significance
mtrB 3625765 c.849C>G synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.38 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625849 c.-939T>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3625876 c.738G>C synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625900 c.-990G>C upstream_gene_variant 0.33 bedaquiline
rifampicin
lpqB 3625903 c.-993G>C upstream_gene_variant 0.33 bedaquiline
rifampicin
lpqB 3625909 c.-999T>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3625927 c.687T>C synonymous_variant 0.28 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.19 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3626927 c.-314G>C upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3626957 c.-344G>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCA frameshift_variant&missense_variant 0.32 bedaquiline
rifampicin
mtrB 3627314 c.-701C>T upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrA 3627343 p.Thr3Ser missense_variant 0.35 bedaquiline
rifampicin
fbiA 3640900 p.Gln120Lys missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiB 3640914 c.-621C>G upstream_gene_variant 0.18 clofazimine
pretomanid
delamanid
fbiA 3640930 p.Glu130Thr missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiB 3640935 c.-600C>G upstream_gene_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3640938 c.-597A>G upstream_gene_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3640944 c.-591T>C upstream_gene_variant 0.21 clofazimine
pretomanid
delamanid
fbiB 3640962 c.-573C>G upstream_gene_variant 0.21 clofazimine
pretomanid
delamanid
alr 3841546 c.-126C>A upstream_gene_variant 1.0 cycloserine
rpoA 3877503 c.1005G>C synonymous_variant 0.3 rifampicin
rpoA 3877507 p.Gly334Ala missense_variant 0.29 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.4 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.38 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.4 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.42 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.36 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.38 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.32 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.26 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.38 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.39 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.41 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.41 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.42 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.41 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.41 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.38 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.37 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877989 c.519A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.25 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.25 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.25 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>A synonymous_variant 0.23 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.24 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.2 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.23 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.21 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.19 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.22 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.19 rifampicin
rpoA 3878169 c.339G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.22 rifampicin
rpoA 3878181 c.327C>T synonymous_variant 0.24 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.2 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.23 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.28 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.31 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.44 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.5 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878340 c.168C>T synonymous_variant 0.43 rifampicin
rpoA 3878346 c.162T>C synonymous_variant 0.45 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.46 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.46 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.47 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.47 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.49 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.5 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.46 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.5 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.5 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.48 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.35 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.39 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.42 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.42 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.45 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.39 rifampicin Uncertain significance
rpoA 3878962 c.-455G>A upstream_gene_variant 0.37 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.33 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.29 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.3 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.28 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.32 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.33 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.34 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.31 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.31 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.35 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.33 rifampicin
clpC1 4038287 c.2418C>T synonymous_variant 0.78 pyrazinamide Not assoc w R
clpC1 4038293 c.2412G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.23 pyrazinamide
clpC1 4038308 c.2395_2397delGTGinsAT frameshift_variant&missense_variant 0.23 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038320 c.2385G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.26 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.23 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.19 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.19 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.19 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.21 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.21 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.19 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.34 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.35 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.37 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.39 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.35 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.33 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.31 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.3 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.3 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.47 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.47 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.47 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.45 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.47 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.5 pyrazinamide
clpC1 4038821 c.1884G>A synonymous_variant 0.45 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.41 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.37 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.36 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.29 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.28 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.32 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.36 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.38 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.39 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.34 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039229 c.1476C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039622 c.1083C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039625 c.1080G>A synonymous_variant 0.2 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.24 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.3 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.31 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.33 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.26 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.3 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.27 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.25 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.25 pyrazinamide
panD 4044712 c.-431C>A upstream_gene_variant 0.22 pyrazinamide
panD 4044725 c.-444C>T upstream_gene_variant 0.28 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.3 pyrazinamide
panD 4044746 c.-467_-465delGTGinsAC upstream_gene_variant 0.31 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.3 pyrazinamide
panD 4044758 c.-477C>T upstream_gene_variant 0.29 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.32 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.32 pyrazinamide
panD 4044791 c.-510G>C upstream_gene_variant 0.33 pyrazinamide
panD 4044800 c.-519C>G upstream_gene_variant 0.35 pyrazinamide
panD 4044812 c.-531A>C upstream_gene_variant 0.36 pyrazinamide
panD 4044818 c.-538_-537delCGinsAC upstream_gene_variant 0.35 pyrazinamide
panD 4044823 c.-542G>C upstream_gene_variant 0.35 pyrazinamide
glpK 4138460 c.1296C>T synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138472 c.1284G>T synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138475 c.1281C>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138490 c.1266G>T synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138670 c.1086G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.21 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138695 p.Pro354Asp missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138763 c.993G>A synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138769 c.987G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139177 c.579T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139183 c.573T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139186 c.570G>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139601 p.Arg52Gln missense_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139611 p.Ile49Val missense_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139615 c.141G>A synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
embC 4240819 c.957A>G synonymous_variant 0.26 ethambutol
embC 4240828 c.966G>C synonymous_variant 0.29 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.29 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.3 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.3 ethambutol
embC 4240873 c.1011C>G synonymous_variant 0.3 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.3 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.3 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.29 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.26 ethambutol Not assoc w R
embC 4240898 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.26 ethambutol
embC 4240903 c.1041C>G synonymous_variant 0.26 ethambutol
embC 4240911 p.Ala350Val missense_variant 0.27 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.3 ethambutol
embC 4240924 c.1062C>G synonymous_variant 0.29 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.25 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4242820 c.-413G>C upstream_gene_variant 0.21 ethambutol
embA 4242823 c.-410G>C upstream_gene_variant 0.21 ethambutol
embA 4242832 c.-401A>C upstream_gene_variant 0.21 ethambutol
embA 4242838 c.-395C>G upstream_gene_variant 0.2 ethambutol
embC 4242841 c.2979C>T synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embA 4242844 c.-389A>G upstream_gene_variant 0.19 ethambutol
embA 4242847 c.-386C>A upstream_gene_variant 0.19 ethambutol
embA 4245060 c.1828T>C synonymous_variant 0.33 ethambutol
embA 4245083 c.1851A>C synonymous_variant 0.4 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.38 ethambutol
embA 4245092 c.1860C>G synonymous_variant 0.4 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.41 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.34 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.38 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.38 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.39 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.41 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.39 ethambutol
embB 4247839 c.1326G>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.2 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.27 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.29 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.27 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.27 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.26 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.27 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.27 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4248304 c.1791G>C synonymous_variant 0.27 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.3 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.3 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.3 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.31 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.33 ethambutol
embB 4248361 c.1848A>C synonymous_variant 0.33 ethambutol
embB 4248362 p.Ser617Ala missense_variant 0.33 ethambutol
embB 4248373 c.1860C>G synonymous_variant 0.33 ethambutol
embB 4248386 c.1873C>A synonymous_variant 0.33 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.25 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.24 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.24 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.23 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.23 ethambutol
embB 4249543 c.3030G>C synonymous_variant 0.23 ethambutol
embB 4249546 c.3033G>A synonymous_variant 0.23 ethambutol
embB 4249558 c.3045A>C synonymous_variant 0.22 ethambutol
ubiA 4269820 p.Val5Gly missense_variant 1.0 ethambutol Uncertain significance
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R