TB-Profiler result

Run: SRR10397124
Summary

Run ID: SRR10397124

Sample name:

Date: 02-04-2023 17:33:28

Number of reads: 1547947

Percentage reads mapped: 99.47

Strain: lineage4.8

Drug-resistance: HR-TB

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
katG 2154820 c.1291delG frameshift_variant 1.0 isoniazid
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6267 p.Pro343Leu missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
rpoB 761095 c.1290_1292dupGAG disruptive_inframe_insertion 1.0
rpoC 765617 p.Glu750Gln missense_variant 0.87
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 775963 p.Val840Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168149 p.Pro822Ser missense_variant 1.0
PPE35 2169029 p.Asp528Glu missense_variant 0.2
Rv1979c 2223086 p.Ile27Leu missense_variant 0.12
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
thyA 3074297 p.Leu59Met missense_variant 0.11
Rv3083 3448497 c.-7T>A upstream_gene_variant 1.0
rpoA 3878630 c.-123G>C upstream_gene_variant 0.11
clpC1 4039729 p.Asp326Asn missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448500 c.-3_*1408del transcript_ablation 1.0