Run ID: SRR13837608
Sample name:
Date: 2025-02-11T15:09:18.810347
Number of reads: 294033
Percentage reads mapped: 99.07
Median coverage: 10.0
Strain: lineage4.9
Spoligotype:
Drug-resistance: Sensitive
| Lineage | Family | RDs | Frequency |
|---|---|---|---|
| lineage4 | Euro-American | None | 1.0 |
| lineage4.9 | Euro-American (H37Rv-like) | None | 1.0 |
| Drug | Resistance | Supporting mutations | WHO confidence | Comment |
|---|---|---|---|---|
| rifampicin | ||||
| isoniazid | ||||
| ethambutol | ||||
| pyrazinamide | ||||
| streptomycin | ||||
| fluoroquinolones | ||||
| moxifloxacin | ||||
| ofloxacin | ||||
| levofloxacin | ||||
| ciprofloxacin | ||||
| aminoglycosides | ||||
| amikacin | ||||
| capreomycin | ||||
| kanamycin | ||||
| cycloserine | ||||
| ethionamide | ||||
| clofazimine | ||||
| para-aminosalicylic_acid | ||||
| delamanid | ||||
| bedaquiline | ||||
| linezolid |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
|---|
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
|---|---|---|---|---|---|---|
| gyrB | 6624 | p.Ser462* | stop_gained | 1.0 | levofloxacin | Uncertain significance |
| moxifloxacin | ||||||
| gyrA | 7285 | c.-17T>C | upstream_gene_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| mmaA3 | 737872 | p.Asp93Ala | missense_variant | 1.0 | isoniazid | |
| mmaA3 | 738202 | c.-53A>C | upstream_gene_variant | 1.0 | isoniazid | |
| rpoC | 764438 | c.1069_1070insA | frameshift_variant | 1.0 | rifampicin | |
| mmpL5 | 775795 | p.Ala896Ser | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| fbiC | 1303593 | c.663G>A | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| rpsA | 1833352 | c.-190C>A | upstream_gene_variant | 1.0 | pyrazinamide | |
| ndh | 2102326 | c.717G>T | synonymous_variant | 1.0 | isoniazid | |
| delamanid | ||||||
| ethionamide | ||||||
| Rv1979c | 2222936 | p.Ala77Thr | missense_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| Rv2477c | 2782975 | c.1068C>T | synonymous_variant | 1.0 | kanamycin | Not assoc w R - Interim |
| levofloxacin | Not assoc w R - Interim | |||||
| moxifloxacin | Not assoc w R - Interim | |||||
| streptomycin | Not assoc w R - Interim | |||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | Not assoc w R - Interim | |||||
| amikacin | Not assoc w R - Interim | |||||
| ald | 3087394 | p.Ala192Val | missense_variant | 1.0 | cycloserine | |
| ald | 3087512 | c.693T>A | synonymous_variant | 1.0 | cycloserine | |
| lpqB | 3623311 | p.Pro534Ser | missense_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3623400 | p.Val504Glu | missense_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624438 | p.Gln158Leu | missense_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| rpoA | 3879111 | c.-604G>C | upstream_gene_variant | 1.0 | rifampicin | |
| embC | 4241874 | p.Leu671Arg | missense_variant | 1.0 | ethambutol | |
| embC | 4242816 | p.Trp985* | stop_gained | 1.0 | ethambutol | |
| embB | 4248365 | p.Val618Met | missense_variant | 1.0 | ethambutol | Uncertain significance |
| aftB | 4267893 | p.Ile315Ser | missense_variant | 1.0 | ethambutol | |
| aftB | 4268516 | c.321A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| ethR | 4326691 | c.-858C>A | upstream_gene_variant | 1.0 | ethionamide |
