Run ID: SRR13837618
Sample name:
Date: 2024-10-04T23:33:11.895847
Number of reads: 293814
Percentage reads mapped: 98.01
Median coverage: 10.0
Strain: lineage4.9
Spoligotype:
Drug-resistance: Sensitive
| Lineage | Family | RDs | Frequency |
|---|---|---|---|
| lineage4 | Euro-American | None | 1.0 |
| lineage4.9 | Euro-American (H37Rv-like) | None | 1.0 |
| Drug | Resistance | Supporting mutations | WHO confidence | Comment |
|---|---|---|---|---|
| rifampicin | ||||
| isoniazid | ||||
| ethambutol | ||||
| pyrazinamide | ||||
| streptomycin | ||||
| fluoroquinolones | ||||
| moxifloxacin | ||||
| ofloxacin | ||||
| levofloxacin | ||||
| ciprofloxacin | ||||
| aminoglycosides | ||||
| amikacin | ||||
| capreomycin | ||||
| kanamycin | ||||
| cycloserine | ||||
| ethionamide | ||||
| clofazimine | ||||
| para-aminosalicylic_acid | ||||
| delamanid | ||||
| bedaquiline | ||||
| linezolid |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
|---|
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
|---|---|---|---|---|---|---|
| Rv1129c | 1253885 | p.Lys217Arg | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| embR | 1417793 | c.-446C>T | upstream_gene_variant | 1.0 | ethambutol | |
| rrs | 1471943 | n.98T>C | non_coding_transcript_exon_variant | 1.0 | kanamycin | Uncertain significance |
| capreomycin | Uncertain significance | |||||
| streptomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| rrs | 1472075 | n.230A>C | non_coding_transcript_exon_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| streptomycin | ||||||
| amikacin | ||||||
| rrs | 1473066 | n.1221A>T | non_coding_transcript_exon_variant | 1.0 | kanamycin | |
| capreomycin | ||||||
| streptomycin | ||||||
| amikacin | ||||||
| inhA | 1674784 | p.Arg195Gly | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| ndh | 2101793 | p.Trp417* | stop_gained | 1.0 | isoniazid | Uncertain significance |
| delamanid | Uncertain significance | |||||
| ethionamide | Uncertain significance | |||||
| ahpC | 2726213 | c.21C>T | synonymous_variant | 1.0 | isoniazid | |
| Rv2477c | 2783213 | p.Ala277Val | missense_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | Uncertain significance | |||||
| rifampicin | Uncertain significance | |||||
| ethambutol | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| Rv2477c | 2783662 | p.Glu127Asp | missense_variant | 1.0 | kanamycin | Uncertain significance |
| levofloxacin | Uncertain significance | |||||
| moxifloxacin | Uncertain significance | |||||
| streptomycin | ||||||
| rifampicin | Uncertain significance | |||||
| ethambutol | ||||||
| amikacin | Uncertain significance | |||||
| Rv2477c | 2784275 | c.-234dupC | upstream_gene_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2680 | 2996618 | p.Trp172Arg | missense_variant | 1.0 | capreomycin | |
| Rv2681 | 2997515 | c.777T>G | synonymous_variant | 1.0 | capreomycin | |
| Rv2752c | 3065644 | p.Thr183Ser | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| lpqB | 3624763 | p.Val50Leu | missense_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625054 | c.-144C>G | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| embB | 4248920 | p.Val803Met | missense_variant | 1.0 | ethambutol | Uncertain significance |
| gid | 4408480 | c.-278G>C | upstream_gene_variant | 1.0 | streptomycin |
