TB-Profiler result

Run: SRR14781971

Summary

Run ID: SRR14781971

Sample name:

Date: 03-04-2023 11:07:16

Number of reads: 1821512

Percentage reads mapped: 99.63

Strain: lineage4.8

Drug-resistance: HR-TB


Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 0.98
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
katG 2155168 p.Ser315Thr missense_variant 0.97 isoniazid
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303747 p.Thr273Ala missense_variant 0.98
Rv1258c 1406166 p.Leu392Pro missense_variant 0.34
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.98
fabG1 1673553 p.Asp38Glu missense_variant 0.15
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2170065 p.Ala183Gly missense_variant 0.36
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
folC 2747556 p.Thr15Ala missense_variant 1.0
ald 3086706 c.-114T>G upstream_gene_variant 1.0
ald 3087899 c.1080G>C synonymous_variant 1.0
fbiD 3339734 p.Ala206Gly missense_variant 0.43
fbiD 3339746 p.Ala210Gly missense_variant 0.22
whiB7 3568428 c.252A>G synonymous_variant 0.36
rpoA 3878590 c.-83G>C upstream_gene_variant 0.22
rpoA 3878613 c.-106A>C upstream_gene_variant 0.67
rpoA 3878641 c.-134C>G upstream_gene_variant 0.33
embC 4240409 p.Pro183Ala missense_variant 0.14
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246527 p.Ala5Gly missense_variant 0.11
embB 4248328 c.1815G>C synonymous_variant 0.14
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
whiB6 4338720 c.-199G>A upstream_gene_variant 0.95
gid 4407766 p.Thr146Lys missense_variant 0.98
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0