TB-Profiler result

Run: SRR14782075

Summary

Run ID: SRR14782075

Sample name:

Date: 03-04-2023 11:11:37

Number of reads: 5343062

Percentage reads mapped: 99.67

Strain: lineage4.8

Drug-resistance: Sensitive


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 0.99
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 9647 c.2346C>G synonymous_variant 0.22
mshA 576108 p.Ala254Gly missense_variant 0.14
mshA 576442 p.Cys365Trp missense_variant 0.17
ccsA 619946 p.Thr19Asn missense_variant 0.99
rpoC 764367 p.Gly333Ala missense_variant 0.32
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777883 p.Gly200Arg missense_variant 0.17
mmpL5 778864 c.-384C>T upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
rrl 1476103 n.2446C>T non_coding_transcript_exon_variant 0.99
fabG1 1673553 p.Asp38Glu missense_variant 0.28
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168149 p.Pro822Ser missense_variant 0.99
PPE35 2170065 p.Ala183Gly missense_variant 0.29
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289894 c.-653G>A upstream_gene_variant 0.97
kasA 2519071 p.Asp319Glu missense_variant 0.13
pepQ 2860159 p.Ala87Gly missense_variant 0.14
ald 3087816 p.Cys333Gly missense_variant 0.13
fbiD 3339734 p.Ala206Gly missense_variant 0.8
fbiD 3339751 p.Ala212Pro missense_variant 0.33
fprA 3474213 p.Lys69Asn missense_variant 0.15
whiB7 3568425 c.255T>G synonymous_variant 0.23
whiB7 3568428 c.252A>G synonymous_variant 0.44
rpoA 3878590 c.-83G>C upstream_gene_variant 0.3
rpoA 3878641 c.-134C>G upstream_gene_variant 0.7
embC 4240409 p.Pro183Ala missense_variant 0.3
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246527 p.Ala5Gly missense_variant 0.53
embB 4246529 p.Ser6Gly missense_variant 0.21
embB 4246584 p.Arg24Pro missense_variant 0.14
embB 4247016 p.Ser168Trp missense_variant 0.18
embB 4248328 c.1815G>C synonymous_variant 0.27
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408099 p.Leu35Arg missense_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0