TB-Profiler result

Run: SRR16088138
Summary

Run ID: SRR16088138

Sample name:

Date: 03-04-2023 16:04:08

Number of reads: 3835760

Percentage reads mapped: 99.68

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 9647 c.2346C>G synonymous_variant 0.24
mshA 576442 p.Cys365Trp missense_variant 0.21
mshA 576613 c.1266A>C synonymous_variant 0.29
mshA 576616 c.1269G>C synonymous_variant 0.33
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777883 p.Gly200Arg missense_variant 0.17
mmpL5 778107 p.Ser125Cys missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
fabG1 1673553 p.Asp38Glu missense_variant 0.16
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168149 p.Pro822Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2519071 p.Asp319Glu missense_variant 0.25
Rv2752c 3064823 p.Val457Leu missense_variant 0.15
fbiD 3339734 p.Ala206Gly missense_variant 0.56
fbiD 3339746 p.Ala210Gly missense_variant 0.29
fbiD 3339751 p.Ala212Pro missense_variant 0.12
Rv3083 3448497 c.-7T>A upstream_gene_variant 1.0
whiB7 3568425 c.255T>G synonymous_variant 0.25
whiB7 3568428 c.252A>G synonymous_variant 0.27
whiB7 3568431 c.249C>G synonymous_variant 0.28
rpoA 3878597 c.-90G>C upstream_gene_variant 0.67
rpoA 3878641 c.-134C>G upstream_gene_variant 0.88
embC 4240409 p.Pro183Ala missense_variant 0.29
embC 4242528 p.Gly889Ala missense_variant 0.14
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246527 p.Ala5Gly missense_variant 0.26
embB 4246529 p.Ser6Arg missense_variant 0.23
embB 4248328 c.1815G>C synonymous_variant 0.27
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0