TB-Profiler result

Run: SRR21678361
Summary

Run ID: SRR21678361

Sample name:

Date: 04-04-2023 02:50:48

Number of reads: 414966

Percentage reads mapped: 99.71

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5596 c.357T>G synonymous_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 8576 c.1275C>T synonymous_variant 0.11
rpoB 759620 c.-187A>C upstream_gene_variant 0.33
rpoB 762847 p.Pro1014Gln missense_variant 0.13
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303016 p.Val29Gly missense_variant 0.3
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1473902 n.245T>C non_coding_transcript_exon_variant 0.15
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
fabG1 1673593 p.Pro52Thr missense_variant 0.2
rpsA 1833504 c.-38_-37insC upstream_gene_variant 0.15
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv1979c 2221954 p.His404Arg missense_variant 0.14
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
folC 2746745 p.Val285Gly missense_variant 0.33
Rv2752c 3065670 c.522C>T synonymous_variant 1.0
thyA 3074231 p.Asp81Asn missense_variant 1.0
whiB7 3568517 c.162delC frameshift_variant 0.14
fbiB 3641992 p.Gly153Glu missense_variant 0.14
alr 3840764 c.657G>C synonymous_variant 1.0
alr 3840894 p.Leu176Pro missense_variant 0.11
embC 4241814 p.Ser651Leu missense_variant 0.18
embC 4241967 p.Gly702Val missense_variant 0.13
embC 4242497 p.Arg879Gly missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4245062 p.Leu610Phe missense_variant 0.18
embB 4249334 p.Ala941Thr missense_variant 0.12
aftB 4267185 p.Pro551Leu missense_variant 0.13
ethA 4326512 p.Thr321Ile missense_variant 0.15
ethA 4326706 p.Trp256Cys missense_variant 0.15
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0