TB-Profiler result

Run: SRR21700835
Summary

Run ID: SRR21700835

Sample name:

Date: 2024-10-05T12:03:19.577075

Number of reads: 6470479

Percentage reads mapped: 99.97

Median coverage: 221.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
mshA 576179 p.Lys278Gln missense_variant 1.0 isoniazid
ethionamide
Rv0565c 656842 p.Gln210Arg missense_variant 0.99 ethionamide
Rv1258c 1406686 p.Val219Ile missense_variant 1.0 streptomycin
pyrazinamide
isoniazid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
Rv3083 3449234 p.Arg244His missense_variant 0.55 ethionamide
ubiA 4269190 p.Ser215Asn missense_variant 1.0 ethambutol
ethA 4326842 p.Tyr211Cys missense_variant 1.0 ethionamide Uncertain significance