TB-Profiler result

Run: SRR4033226

Summary

Run ID: SRR4033226

Sample name:

Date: 04-04-2023 05:55:41

Number of reads: 1089011

Percentage reads mapped: 99.78

Strain: lineage4.8.1

Drug-resistance: Sensitive


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
lineage4.8.1 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
rpoB 762128 c.2322G>A synonymous_variant 0.14
rpoB 762173 p.Glu789Asp missense_variant 0.1
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpR5 779125 p.Cys46Arg missense_variant 0.12
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303016 p.Val29Gly missense_variant 0.15
Rv1258c 1407023 c.318G>A synonymous_variant 0.11
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1473349 n.1505delT non_coding_transcript_exon_variant 0.12
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2155836 c.276C>A synonymous_variant 0.12
PPE35 2168149 p.Pro822Ser missense_variant 1.0
PPE35 2169320 p.Leu431Phe missense_variant 0.29
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
folC 2746411 c.1187delC frameshift_variant 0.15
folC 2746607 p.Ala331Val missense_variant 0.13
ribD 2987307 p.Ala157Pro missense_variant 0.22
ald 3087144 c.326delA frameshift_variant 0.11
fbiD 3339040 c.-78T>C upstream_gene_variant 1.0
fbiB 3642414 p.Pro294Ser missense_variant 0.11
fbiB 3642421 p.Arg296Gln missense_variant 0.11
fbiB 3642874 p.Leu447Arg missense_variant 1.0
alr 3840954 p.Val156Ala missense_variant 0.12
rpoA 3878239 p.Asp90Val missense_variant 0.12
clpC1 4038857 c.1848C>A synonymous_variant 0.27
clpC1 4039091 c.1614G>A synonymous_variant 0.1
embC 4239842 c.-21C>A upstream_gene_variant 0.14
embA 4242475 c.-758G>A upstream_gene_variant 0.13
embA 4242643 c.-590C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448497 c.-6_*1408del transcript_ablation 1.0