TB-Profiler result

Run: SRR4033265
Summary

Run ID: SRR4033265

Sample name:

Date: 04-04-2023 05:57:17

Number of reads: 1327066

Percentage reads mapped: 99.78

Strain: lineage4.8.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
lineage4.8.1 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
fgd1 491236 p.Gly152Cys missense_variant 0.17
mshA 576125 p.Gly260* stop_gained 0.2
rpoB 762982 p.Gly1059Val missense_variant 0.11
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776014 p.Trp823Arg missense_variant 0.12
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
embR 1416898 c.450C>T synonymous_variant 0.1
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154329 p.Arg595Gly missense_variant 0.1
katG 2154938 p.Arg392Trp missense_variant 0.12
katG 2155787 p.Ala109Thr missense_variant 0.12
katG 2156414 c.-303T>C upstream_gene_variant 0.15
PPE35 2168149 p.Pro822Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
fbiD 3339040 c.-78T>C upstream_gene_variant 1.0
Rv3236c 3613065 p.Leu18Phe missense_variant 0.12
fbiA 3640659 p.His39Gln missense_variant 0.12
fbiA 3641129 p.Ala196Val missense_variant 0.12
fbiB 3642874 p.Leu447Arg missense_variant 1.0
clpC1 4038448 p.Asp753Tyr missense_variant 0.12
clpC1 4039257 p.Gln483Arg missense_variant 0.11
embC 4242425 p.Arg855Gly missense_variant 0.2
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242822 p.Val987Gly missense_variant 0.18
embB 4248897 c.2389_2390delAC frameshift_variant 0.1
aftB 4268302 p.Ala179Thr missense_variant 0.12
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407915 c.288C>T synonymous_variant 0.11
Rv3083 3448484 c.-19_*1408del transcript_ablation 1.0