TB-Profiler result

Run: SRR4033287
Summary

Run ID: SRR4033287

Sample name:

Date: 04-04-2023 05:58:15

Number of reads: 981530

Percentage reads mapped: 99.77

Strain: lineage4.8.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
lineage4.8.1 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
ccsA 620130 c.240G>A synonymous_variant 0.15
rpoB 763135 p.Gly1110Asp missense_variant 0.11
rpoC 767082 p.Ile1238Thr missense_variant 0.12
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781651 p.Arg31Leu missense_variant 0.11
fbiC 1302897 c.-34G>A upstream_gene_variant 0.12
fbiC 1304457 p.Cys509Trp missense_variant 0.18
fbiC 1305485 p.Ala852Val missense_variant 0.12
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
fabG1 1674076 p.Thr213Pro missense_variant 0.17
rpsA 1834110 p.Trp190Leu missense_variant 0.13
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154609 c.1503A>G synonymous_variant 0.12
PPE35 2168149 p.Pro822Ser missense_variant 1.0
PPE35 2169320 p.Leu431Phe missense_variant 0.19
PPE35 2170476 p.Gly46Asp missense_variant 0.17
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518998 p.Leu295Pro missense_variant 0.14
ahpC 2726338 p.Val49Gly missense_variant 0.16
fbiD 3339040 c.-78T>C upstream_gene_variant 1.0
Rv3083 3448497 c.-7T>A upstream_gene_variant 1.0
fbiB 3642874 p.Leu447Arg missense_variant 1.0
alr 3840387 p.Gln345Leu missense_variant 0.17
rpoA 3877532 p.Ala326Thr missense_variant 0.12
clpC1 4038857 c.1848C>A synonymous_variant 0.23
panD 4043898 c.384G>A synonymous_variant 0.14
embA 4242643 c.-590C>T upstream_gene_variant 1.0
aftB 4267035 p.Arg601Pro missense_variant 0.12
aftB 4268263 c.573_574insC frameshift_variant 0.14
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0