TB-Profiler result

Run: SRR4037726
Summary

Run ID: SRR4037726

Sample name:

Date: 04-04-2023 07:37:06

Number of reads: 495778

Percentage reads mapped: 99.68

Strain: lineage4.4.1.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.4 Euro-American S;T None 1.0
lineage4.4.1.1 Euro-American S;Orphans None 0.97
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5519 p.Pro94Thr missense_variant 0.29
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9138 p.Gln613Glu missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
ccsA 620861 p.Gly324Asp missense_variant 0.25
rpoC 765817 c.2448G>A synonymous_variant 0.17
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777416 c.1065G>T synonymous_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406599 p.Pro248Thr missense_variant 0.2
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
inhA 1673363 c.-839G>A upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102990 p.Val18Ala missense_variant 1.0
katG 2155659 c.453C>A synonymous_variant 0.17
PPE35 2168479 p.Thr712Pro missense_variant 1.0
PPE35 2169320 p.Leu431Phe missense_variant 0.31
PPE35 2169840 p.Gly258Asp missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ribD 2986994 c.156C>T synonymous_variant 0.17
Rv2752c 3066175 p.Pro6Arg missense_variant 1.0
thyX 3067763 c.183C>A synonymous_variant 0.29
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3086995 p.Gly59Asp missense_variant 0.12
Rv3083 3448608 c.105G>A synonymous_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
whiB7 3568779 c.-100T>C upstream_gene_variant 1.0
Rv3236c 3612665 p.Val151Ala missense_variant 1.0
panD 4044080 p.Val68Met missense_variant 0.12
embC 4240522 c.660C>T synonymous_variant 0.18
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4245013 p.Arg594His missense_variant 0.2
embA 4245675 p.Gly815Trp missense_variant 0.29
embB 4248535 c.2022C>T synonymous_variant 0.11
aftB 4268343 p.Arg165His missense_variant 0.14
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408449 c.-247C>A upstream_gene_variant 0.12