TB-Profiler result

Run: SRR5485453
Summary

Run ID: SRR5485453

Sample name:

Date: 18-08-2022 08:31:05

Number of reads: 126941

Percentage reads mapped: 98.24

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 1.0 streptomycin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289180 p.Val21Gly missense_variant 0.14 pyrazinamide
embB 4247431 p.Met306Ile missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
rpoB 761059 p.Val418Gly missense_variant 0.15
rpoB 761228 p.Tyr474* stop_gained 0.18
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.3
rrl 1473502 n.-156T>G upstream_gene_variant 0.14
pncA 2289138 p.Leu35Arg missense_variant 0.14
pncA 2289186 p.Leu19Gln missense_variant 0.14
pncA 2289224 c.18C>T synonymous_variant 0.14
pncA 2289240 c.2T>C start_lost 1.0
embB 4247577 p.Leu355Arg missense_variant 0.14