TB-Profiler result

Run: SRR5485482
Summary

Run ID: SRR5485482

Sample name:

Date: 18-08-2022 08:29:06

Number of reads: 119111

Percentage reads mapped: 99.06

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 1.0 streptomycin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289231 p.Leu4Ser missense_variant 1.0 pyrazinamide
embB 4247399 p.Asn296His missense_variant 0.15 ethambutol
embB 4247429 p.Met306Val missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.36
rrs 1473251 n.1406A>G non_coding_transcript_exon_variant 0.14
rrs 1473296 n.1451G>A non_coding_transcript_exon_variant 0.14
fabG1 1673395 c.-45C>T upstream_gene_variant 0.2
pncA 2288924 p.Phe106Leu missense_variant 0.18
embB 4247352 p.Asp280Ala missense_variant 0.15
embB 4247363 p.Ile284Leu missense_variant 0.15
embB 4247383 p.Trp290Cys missense_variant 0.15
embB 4247420 p.Ile303Leu missense_variant 0.15
embB 4247448 p.His312Pro missense_variant 0.15