TB-Profiler result

Run: SRR5485483
Summary

Run ID: SRR5485483

Sample name:

Date: 18-08-2022 08:29:06

Number of reads: 129583

Percentage reads mapped: 99.18

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 1.0 streptomycin
rrs 1473246 n.1401A>G non_coding_transcript_exon_variant 1.0 kanamycin, capreomycin, aminoglycosides, amikacin
fabG1 1673424 c.-16A>G upstream_gene_variant 0.18 isoniazid
embB 4247431 p.Met306Ile missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6746 p.Gln503Lys missense_variant 0.2
gyrB 6750 p.Ala504Glu missense_variant 0.2
rpoB 761228 p.Tyr474* stop_gained 0.15
rrs 1472302 n.457G>C non_coding_transcript_exon_variant 0.15
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.3
pncA 2288944 p.Thr100Pro missense_variant 1.0
pncA 2289210 p.Asn11Ser missense_variant 0.14
embB 4247348 p.Thr279Pro missense_variant 0.19