TB-Profiler result

Run: SRR5485517
Summary

Run ID: SRR5485517

Sample name:

Date: 18-08-2022 08:33:24

Number of reads: 127960

Percentage reads mapped: 98.29

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761077 p.Phe424Ser missense_variant 0.18 rifampicin
rpoB 761110 p.Asp435Val missense_variant 1.0 rifampicin
rrs 1472359 n.514A>C non_coding_transcript_exon_variant 0.98 streptomycin
rrs 1473246 n.1401A>G non_coding_transcript_exon_variant 0.9 kanamycin, capreomycin, aminoglycosides, amikacin
fabG1 1673425 c.-15C>T upstream_gene_variant 1.0 isoniazid, ethionamide
pncA 2288817 p.Thr142Met missense_variant 1.0 pyrazinamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6501 p.Arg421Pro missense_variant 0.2
gyrB 6615 p.Glu459Val missense_variant 0.15
gyrA 7597 c.298delG frameshift_variant 0.2
gyrA 7615 p.Leu105Gln missense_variant 0.2
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.47
rrs 1472572 n.727T>C non_coding_transcript_exon_variant 0.24