TB-Profiler result

Run: SRR5485546
Summary

Run ID: SRR5485546

Sample name:

Date: 18-08-2022 08:27:19

Number of reads: 73499

Percentage reads mapped: 98.9

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
rrs 1472751 n.906A>G non_coding_transcript_exon_variant 1.0 streptomycin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2288930 p.Ser104Arg missense_variant 1.0 pyrazinamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6650 p.Arg471Cys missense_variant 0.17
rpoB 761117 c.1311C>T synonymous_variant 0.17
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.37
rrs 1473370 n.1525T>C non_coding_transcript_exon_variant 0.14
katG 2155091 p.Trp341Gly missense_variant 0.18
pncA 2288916 p.Val109Gly missense_variant 0.14
pncA 2288924 p.Phe106Val missense_variant 0.14
embB 4247465 p.Asn318Arg missense_variant 0.18