TB-Profiler result

Run: SRR5485563
Summary

Run ID: SRR5485563

Sample name:

Date: 18-08-2022 08:25:57

Number of reads: 129489

Percentage reads mapped: 99.17

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 0.93 rifampicin
rrs 1472362 n.517C>T non_coding_transcript_exon_variant 0.95 streptomycin
fabG1 1673425 c.-15C>T upstream_gene_variant 1.0 isoniazid, ethionamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
rpoB 761228 p.Tyr474* stop_gained 0.15
rpsL 781843 p.Tyr95Ser missense_variant 0.14
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.26
rrl 1473506 n.-152G>T upstream_gene_variant 0.17
pncA 2288924 p.Phe106Val missense_variant 0.19
pncA 2289264 c.-23T>C upstream_gene_variant 0.14