TB-Profiler result

Run: SRR5485567
Summary

Run ID: SRR5485567

Sample name:

Date: 18-08-2022 08:25:36

Number of reads: 145233

Percentage reads mapped: 99.17

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761110 p.Asp435Val missense_variant 1.0 rifampicin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289114 p.His43Pro missense_variant 0.33 pyrazinamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7529 c.228G>C synonymous_variant 0.2
gyrA 7585 p.Ser95Thr missense_variant 1.0
rpoB 761171 c.1365C>T synonymous_variant 0.15
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.21
rrs 1473261 n.1416G>A non_coding_transcript_exon_variant 0.2
katG 2155091 p.Trp341Gly missense_variant 0.14
katG 2155097 p.Tyr339Asp missense_variant 0.14
pncA 2289047 c.195C>T synonymous_variant 1.0
pncA 2289051 p.Tyr64Ser missense_variant 0.15
embB 4247693 p.Ala394Thr missense_variant 0.18
embB 4247701 p.Met396Ile missense_variant 0.18