TB-Profiler result

Run: SRR5485573
Summary

Run ID: SRR5485573

Sample name:

Date: 18-08-2022 08:25:14

Number of reads: 102518

Percentage reads mapped: 99.27

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 1.0 streptomycin
fabG1 1673425 c.-15C>T upstream_gene_variant 1.0 isoniazid, ethionamide
embB 4247431 p.Met306Ile missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7597 p.Met99Thr missense_variant 0.17
rpoB 761080 p.Phe425Ser missense_variant 0.14
rpsL 781705 p.Leu49Pro missense_variant 0.17
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.25
fabG1 1673402 c.-38A>G upstream_gene_variant 0.14
pncA 2288916 p.Val109Gly missense_variant 0.14
pncA 2289319 c.-78C>G upstream_gene_variant 0.23
eis 2715278 c.55C>T synonymous_variant 0.14
embB 4247596 p.Cys361* stop_gained 0.19