TB-Profiler result

Run: SRR5485601
Summary

Run ID: SRR5485601

Sample name:

Date: 18-08-2022 08:23:04

Number of reads: 102245

Percentage reads mapped: 97.9

Strain:

Drug-resistance: MDR-TB

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761089 p.Ser428Thr missense_variant 0.44 rifampicin
rpoB 761140 p.His445Leu missense_variant 0.39 rifampicin
rpoB 761155 p.Ser450Leu missense_variant 0.63 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 1.0 streptomycin
rrs 1473246 n.1401A>G non_coding_transcript_exon_variant 0.24 kanamycin, capreomycin, aminoglycosides, amikacin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289114 p.His43Pro missense_variant 0.2 pyrazinamide
embB 4247429 p.Met306Val missense_variant 0.19 ethambutol
embB 4247574 p.Asp354Ala missense_variant 0.76 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7666 c.368delC frameshift_variant 0.2
rpsL 781661 p.Cys34Trp missense_variant 0.18
rrs 1472302 n.457G>C non_coding_transcript_exon_variant 0.18
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.23
pncA 2289256 c.-15A>C upstream_gene_variant 0.84