TB-Profiler result

Run: SRR5818412
Summary

Run ID: SRR5818412

Sample name:

Date: 04-04-2023 11:24:50

Number of reads: 517395

Percentage reads mapped: 96.91

Strain: lineage4.9

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 0.99 rifampicin
tlyA 1918647 p.Asn236Lys missense_variant 0.99 capreomycin
katG 2155168 p.Ser315Thr missense_variant 0.89 isoniazid
pncA 2288859 p.Val128Gly missense_variant 0.97 pyrazinamide
embB 4247431 p.Met306Ile missense_variant 0.99 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7585 p.Ser95Thr missense_variant 0.98
tlyA 1917972 c.33A>G synonymous_variant 1.0
ahpC 2726184 c.-9A>C upstream_gene_variant 0.48
ethA 4326764 p.Ala237Val missense_variant 0.26
gid 4407748 p.Leu152Ser missense_variant 0.97