TB-Profiler result

Run: SRR6045376
Summary

Run ID: SRR6045376

Sample name:

Date: 04-04-2023 11:58:08

Number of reads: 1541986

Percentage reads mapped: 93.17

Strain: lineage4.1.2.1

Drug-resistance: HR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.2 Euro-American T;H None 0.99
lineage4.1.2.1 Euro-American (Haarlem) T1;H1 RD182 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpsL 781822 p.Lys88Arg missense_variant 1.0 streptomycin
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.42 streptomycin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
embA 4243221 c.-12C>T upstream_gene_variant 1.0 ethambutol
embB 4248025 p.Glu504Asp missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 490751 c.-32T>G upstream_gene_variant 0.22
fgd1 491027 p.Asn82Thr missense_variant 0.26
fgd1 491591 p.Lys270Met missense_variant 1.0
fgd1 491669 p.Lys296Arg missense_variant 1.0
mshA 575679 p.Asn111Ser missense_variant 1.0
ccsA 619831 c.-60T>G upstream_gene_variant 0.31
rpoB 760115 c.309C>T synonymous_variant 1.0
rpoC 765150 p.Gly594Glu missense_variant 0.98
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.12
rrs 1472326 n.481T>C non_coding_transcript_exon_variant 0.14
rrs 1472507 n.662C>G non_coding_transcript_exon_variant 0.29
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.22
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 0.3
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.33
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.36
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.36
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.36
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.42
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.38
rrs 1472579 n.734G>C non_coding_transcript_exon_variant 0.27
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.25
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.31
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.32
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.26
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.29
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.38
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.28
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.12
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.29
rrs 1472670 n.825G>T non_coding_transcript_exon_variant 0.13
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.27
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 0.2
rrs 1472677 n.832C>T non_coding_transcript_exon_variant 0.17
rrs 1472679 n.834T>C non_coding_transcript_exon_variant 0.15
rrs 1472681 n.837_838delTT non_coding_transcript_exon_variant 0.29
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.29
rrs 1472690 n.845C>A non_coding_transcript_exon_variant 0.44
rrs 1472692 n.847T>C non_coding_transcript_exon_variant 0.2
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.3
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.47
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.2
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.41
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.44
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.44
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.27
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.18
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.27
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.18
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.4
rrl 1474155 n.498G>A non_coding_transcript_exon_variant 0.4
rrl 1474164 n.507C>T non_coding_transcript_exon_variant 0.4
rrl 1474171 n.514C>T non_coding_transcript_exon_variant 0.4
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.4
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.4
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.4
rrl 1474197 n.540C>T non_coding_transcript_exon_variant 0.4
rrl 1474199 n.542G>A non_coding_transcript_exon_variant 0.4
rrl 1474202 n.545T>C non_coding_transcript_exon_variant 0.4
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.29
rrl 1474228 n.571T>C non_coding_transcript_exon_variant 0.33
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.8
rrl 1474252 n.595T>A non_coding_transcript_exon_variant 0.4
rrl 1474275 n.618T>C non_coding_transcript_exon_variant 0.67
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.67
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.67
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.67
rrl 1474709 n.1052G>A non_coding_transcript_exon_variant 0.67
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.67
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.75
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.75
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.75
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.67
rrl 1474780 n.1123C>T non_coding_transcript_exon_variant 0.67
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.67
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.8
rrl 1474801 n.1144G>A non_coding_transcript_exon_variant 0.6
rrl 1474802 n.1145T>C non_coding_transcript_exon_variant 0.6
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.8
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.4
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.4
rrl 1475715 n.2058G>C non_coding_transcript_exon_variant 0.2
rrl 1475751 n.2094C>A non_coding_transcript_exon_variant 0.22
rrl 1475756 n.2099T>C non_coding_transcript_exon_variant 0.18
rrl 1475757 n.2101_2102dupAC non_coding_transcript_exon_variant 0.2
rrl 1475762 n.2105G>C non_coding_transcript_exon_variant 0.2
rrl 1475764 n.2107A>T non_coding_transcript_exon_variant 0.27
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.2
rrl 1475767 n.2112_2113dupTG non_coding_transcript_exon_variant 0.2
rrl 1475777 n.2120A>T non_coding_transcript_exon_variant 0.15
rrl 1475817 n.2160A>G non_coding_transcript_exon_variant 0.12
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.15
rrl 1476225 n.2568T>G non_coding_transcript_exon_variant 0.12
rrl 1476227 n.2570C>T non_coding_transcript_exon_variant 0.11
rrl 1476229 n.2572C>T non_coding_transcript_exon_variant 0.11
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.18
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.18
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.15
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.17
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.16
rrl 1476293 n.2636C>T non_coding_transcript_exon_variant 0.12
rrl 1476294 n.2637A>G non_coding_transcript_exon_variant 0.12
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.12
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.12
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.12
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.12
rrl 1476302 n.2645G>A non_coding_transcript_exon_variant 0.12
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.13
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.13
rrl 1476313 n.2656G>A non_coding_transcript_exon_variant 0.15
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.3
rrl 1476338 n.2681C>T non_coding_transcript_exon_variant 0.26
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.3
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.3
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.12
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.26
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.26
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.12
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.21
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.24
rrl 1476411 n.2754G>T non_coding_transcript_exon_variant 0.11
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.11
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.18
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.12
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.14
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.19
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.18
fabG1 1674076 p.Thr213Pro missense_variant 0.23
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339273 c.156T>G synonymous_variant 0.22
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
rpoA 3878531 c.-24A>G upstream_gene_variant 0.4
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embA 4244905 p.Val558Gly missense_variant 0.2
whiB6 4338595 c.-75delG upstream_gene_variant 0.99