TB-Profiler result

Run: SRR6046447

Summary

Run ID: SRR6046447

Sample name:

Date: 20-10-2023 18:11:36

Number of reads: 2587854

Percentage reads mapped: 96.61

Strain: lineage4.8

Drug-resistance: Sensitive


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6540 p.Asp434Gly missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1305180 c.2250G>A synonymous_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474674 n.1017_1018delACinsG non_coding_transcript_exon_variant 0.38
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.38
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.64
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.69
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.77
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.69
rrl 1474780 n.1123C>T non_coding_transcript_exon_variant 0.69
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.75
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.62
rrl 1474801 n.1144G>A non_coding_transcript_exon_variant 0.6
rrl 1474802 n.1145T>C non_coding_transcript_exon_variant 0.6
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.67
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.6
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.6
rrl 1474832 n.1175A>T non_coding_transcript_exon_variant 0.6
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.56
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.27
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.29
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168149 p.Pro822Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
clpC1 4039729 p.Asp326Asn missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0