Run ID: SRR6152894
Sample name:
Date: 19-10-2023 09:40:47
Number of reads: 5210468
Percentage reads mapped: 99.67
Strain: lineage4.9
Drug-resistance: Other
| Drug | Resistance | Supporting mutations |
|---|---|---|
| Rifampicin | ||
| Isoniazid | ||
| Ethambutol | ||
| Pyrazinamide | ||
| Streptomycin | ||
| Fluoroquinolones | R | gyrB p.Arg446His (0.99) |
| Moxifloxacin | R | gyrB p.Arg446His (0.99) |
| Ofloxacin | R | gyrB p.Arg446His (0.99) |
| Levofloxacin | R | gyrB p.Arg446His (0.99) |
| Ciprofloxacin | R | gyrB p.Arg446His (0.99) |
| Aminoglycosides | ||
| Amikacin | ||
| Capreomycin | ||
| Kanamycin | ||
| Cycloserine | ||
| Ethionamide | ||
| Clofazimine | ||
| Para-aminosalicylic_acid | ||
| Delamanid | ||
| Bedaquiline | ||
| Linezolid |
| Lineage | Family | Main Spoligotype | RDs | Frequency |
|---|---|---|---|---|
| lineage4 | Euro-American | LAM;T;S;X;H | None | 1.0 |
| lineage4.9 | Euro-American (H37Rv-like) | T1 | None | 1.0 |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs |
|---|---|---|---|---|---|
| gyrB | 6576 | p.Arg446His | missense_variant | 0.99 | ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin |
| Gene | Chromosome position | Mutation | Type | Estimated fraction |
|---|---|---|---|---|
| gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 |
| rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 |
| tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 |
| PPE35 | 2169041 | c.1572G>A | synonymous_variant | 0.25 |
| PPE35 | 2169053 | c.1560T>C | synonymous_variant | 1.0 |
| PPE35 | 2169059 | c.1554G>A | synonymous_variant | 1.0 |
| PPE35 | 2169063 | p.Met517Thr | missense_variant | 1.0 |
| PPE35 | 2169065 | p.Ala516Thr | missense_variant | 1.0 |
| PPE35 | 2169068 | c.1545G>T | synonymous_variant | 1.0 |
| embB | 4246903 | c.390G>A | synonymous_variant | 1.0 |
| whiB6 | 4338295 | p.Trp76* | stop_gained | 1.0 |
| whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 |
