TB-Profiler result

Run: SRR6982250
Summary

Run ID: SRR6982250

Sample name:

Date: 04-04-2023 18:31:54

Number of reads: 745110

Percentage reads mapped: 99.56

Strain: lineage4.4.1.1.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.4 Euro-American S;T None 1.0
lineage4.4.1 Euro-American (S-type) S;T None 1.0
lineage4.4.1.1 Euro-American S;Orphans None 1.0
lineage4.4.1.1.1 Euro-American S;Orphans None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8596 p.Ala432Val missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
ccsA 619846 c.-45C>T upstream_gene_variant 0.12
ccsA 619917 c.27C>T synonymous_variant 0.18
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102990 p.Val18Ala missense_variant 1.0
ndh 2103126 c.-84A>T upstream_gene_variant 0.11
katG 2154156 c.1956A>T synonymous_variant 0.1
katG 2155856 p.Thr86Pro missense_variant 0.17
PPE35 2169840 p.Gly258Asp missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2519217 p.Pro368Leu missense_variant 0.13
eis 2714923 p.Leu137Ser missense_variant 0.1
pepQ 2860276 p.Asp48Ala missense_variant 0.12
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3448608 c.105G>A synonymous_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612016 c.1101G>T synonymous_variant 0.11
Rv3236c 3612665 p.Val151Ala missense_variant 1.0
Rv3236c 3612690 p.Leu143Phe missense_variant 0.14
fbiB 3642757 p.Val408Asp missense_variant 0.11
clpC1 4040090 c.615T>C synonymous_variant 0.12
embC 4240648 c.786C>T synonymous_variant 0.13
embC 4241961 p.Leu700Gln missense_variant 0.11
embC 4242054 p.Tyr731Ser missense_variant 0.11
embA 4242391 c.-842G>A upstream_gene_variant 0.14
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243194 c.-39C>T upstream_gene_variant 0.11
embA 4244936 c.1704C>A synonymous_variant 0.1
embB 4246331 c.-183C>A upstream_gene_variant 0.11
embB 4246584 p.Arg24His missense_variant 0.11
embB 4248907 c.2394G>A synonymous_variant 0.11
embB 4248992 p.Asn827Tyr missense_variant 0.13
aftB 4268780 p.Trp19Cys missense_variant 0.13
ubiA 4269745 p.Val30Gly missense_variant 0.11
ubiA 4269754 p.Val27Gly missense_variant 0.11
whiB6 4338277 p.Pro82Leu missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0