TB-Profiler result

Run: SRR6982527
Summary

Run ID: SRR6982527

Sample name:

Date: 04-04-2023 18:40:04

Number of reads: 559662

Percentage reads mapped: 99.55

Strain: lineage4.9.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 0.99
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
lineage4.9.1 Euro-American (H37Rv-like) T1 None 0.97
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 8978 c.1677C>T synonymous_variant 0.96
fgd1 491232 c.450T>C synonymous_variant 0.15
ccsA 620625 p.Ile245Met missense_variant 0.13
rpoB 759745 c.-62C>T upstream_gene_variant 0.96
rpoB 760044 p.Leu80Val missense_variant 0.97
rpoB 761495 p.Glu563Asp missense_variant 0.96
rpoC 767196 c.3829delG frameshift_variant 0.14
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 0.97
embR 1416399 p.Asp317Asn missense_variant 0.11
atpE 1460932 c.-113T>C upstream_gene_variant 0.18
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1473492 n.-166T>C upstream_gene_variant 0.12
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2167743 p.Gly957Asp missense_variant 0.11
PPE35 2168054 c.2559G>T synonymous_variant 0.11
PPE35 2169240 p.Pro458His missense_variant 0.1
PPE35 2169373 p.Thr414Pro missense_variant 0.95
PPE35 2169551 c.1062C>T synonymous_variant 0.14
PPE35 2169629 p.Asn328Lys missense_variant 0.2
PPE35 2169632 c.981C>T synonymous_variant 0.2
Rv1979c 2223145 p.Arg7Lys missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289138 p.Leu35Arg missense_variant 1.0
folC 2746169 p.Ala477Glu missense_variant 0.17
ribD 2986917 p.Glu27* stop_gained 0.11
ald 3087549 p.Ala244Thr missense_variant 0.1
fbiD 3339385 p.Asp90Asn missense_variant 1.0
fbiB 3640614 c.-921C>T upstream_gene_variant 0.11
embA 4244607 p.Leu459Met missense_variant 0.12
embB 4246704 p.Leu64Pro missense_variant 0.1
aftB 4267831 p.Gly336Arg missense_variant 0.2
aftB 4268611 c.225dupG frameshift_variant 0.33
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 0.11
gid 4407627 c.576C>A synonymous_variant 0.12