TB-Profiler result

Run: SRR9166037
Summary

Run ID: SRR9166037

Sample name:

Date: 2024-10-05T14:38:31.573142

Number of reads: 11355849

Percentage reads mapped: 99.89

Median coverage: 216.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
fbiC 1304630 p.Phe567Ser missense_variant 0.56 pretomanid
delamanid
clofazimine
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
bacA 2063436 p.Asp431Glu missense_variant 0.59 kanamycin
capreomycin
streptomycin
amikacin
PPE35 2170598 c.15G>A synonymous_variant 0.98 pyrazinamide
embB 4246555 c.42G>C synonymous_variant 0.18 ethambutol
embB 4246556 p.Ala15Pro missense_variant 0.18 ethambutol Uncertain significance