TB-Profiler result

Run: 0a3fb48d-2ba4-487f-ac35-7f185fa10004
Summary

Run ID: 0a3fb48d-2ba4-487f-ac35-7f185fa10004

Sample name:

Date: 13-12-2023 10:14:25

Number of reads: 1724728

Percentage reads mapped: 100.0

Median coverage: 59

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.1 Euro-American None 1.0
lineage4.1.2 Euro-American None 1.0
lineage4.1.2.1 Euro-American (Haarlem) RD182 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
isoniazid katG p.Ser315Thr Assoc w R
ethambutol
pyrazinamide
moxifloxacin
levofloxacin
bedaquiline mmpR5 c.198dupG Uncertain significance
delamanid
pretomanid
linezolid
streptomycin
amikacin
kanamycin
capreomycin
clofazimine mmpR5 c.198dupG Uncertain significance
ethionamide
para-aminosalicylic_acid
cycloserine
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin Assoc w R
mmpR5 779181 c.198dupG frameshift_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
katG 2155168 p.Ser315Thr missense_variant 0.98 isoniazid Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
fgd1 491591 p.Lys270Met missense_variant 1.0 delamanid Uncertain significance
mshA 575679 p.Asn111Ser missense_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
rpoB 760115 c.309C>T synonymous_variant 1.0 rifampicin
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Uncertain significance
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpR5 778991 p.Val1Ala missense_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Uncertain significance
Rv1258c 1406622 p.Leu240Arg missense_variant 1.0 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 0.98 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrl 1475225 n.1568A>G non_coding_transcript_exon_variant 0.98 linezolid
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
kasA 2518076 c.-39C>T upstream_gene_variant 1.0 isoniazid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
embA 4242643 c.-590C>T upstream_gene_variant 0.98 ethambutol
embC 4242803 p.Val981Leu missense_variant 1.0 ethambutol Uncertain significance