Run ID: DRR474002
Sample name:
Date: 2025-03-07T00:01:36.715284
Number of reads: 2197415
Percentage reads mapped: 99.68
Median coverage: 133.0
Strain: lineage4.9
Spoligotype:
Drug-resistance: RR-TB
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage4 | Euro-American | None | 1.0 |
lineage4.9 | Euro-American (H37Rv-like) | None | 1.0 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | rpoB | p.Ser450Leu | Assoc w R | |
isoniazid | ||||
ethambutol | embB | p.Met306Ile | Assoc w R | |
pyrazinamide | ||||
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | eis | c.-10G>C | Uncertain significance | Mutation from literature |
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
rpoB | 761155 | p.Ser450Leu | missense_variant | 1.0 | rifampicin | Assoc w R | |
eis | 2715342 | c.-10G>C | upstream_gene_variant | 1.0 | kanamycin | Uncertain significance | Mutation from literature |
embB | 4247431 | p.Met306Ile | missense_variant | 1.0 | ethambutol | Assoc w R |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rplC | 801301 | p.Arg165Trp | missense_variant | 1.0 | linezolid | Uncertain significance |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | amikacin | Uncertain significance |
capreomycin | Uncertain significance | |||||
kanamycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
katG | 2156033 | p.Lys27Glu | missense_variant | 1.0 | isoniazid | Uncertain significance |
Rv1979c | 2221857 | c.1308C>T | synonymous_variant | 0.99 | bedaquiline | Uncertain significance |
clofazimine | Uncertain significance | |||||
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
Rv1979c | 2223724 | c.-560C>G | upstream_gene_variant | 0.99 | bedaquiline | Uncertain significance |
clofazimine | Uncertain significance | |||||
pncA | 2288937 | p.Ala102Val | missense_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
Rv2477c | 2782388 | p.His552Arg | missense_variant | 1.0 | amikacin | Uncertain significance |
ethambutol | Uncertain significance | |||||
kanamycin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
moxifloxacin | Uncertain significance | |||||
rifampicin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
rpoA | 3878187 | c.321C>T | synonymous_variant | 1.0 | rifampicin | Uncertain significance |
embA | 4244211 | p.Pro327Ser | missense_variant | 1.0 | ethambutol | Uncertain significance |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | amikacin | Not assoc w R |
capreomycin | Not assoc w R | |||||
kanamycin | Not assoc w R |