TB-Profiler result

Run: ERR040127
Summary

Run ID: ERR040127

Sample name:

Date: 31-03-2023 08:46:29

Number of reads: 17266624

Percentage reads mapped: 99.31

Strain: lineage4.6.1.2

Drug-resistance: MDR-TB

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.6 Euro-American T;LAM None 1.0
lineage4.6.1 Euro-American (Uganda) T2 RD724 1.0
lineage4.6.1.2 Euro-American T2 RD724 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761139 p.His445Asp missense_variant 1.0 rifampicin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
embB 4247431 p.Met306Ile missense_variant 1.0 ethambutol
ethA 4327147 p.Trp109* stop_gained 1.0 ethionamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7539 p.Thr80Ala missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
rpoC 762836 c.-534C>G upstream_gene_variant 0.33
rpoC 764725 p.Phe452Leu missense_variant 0.22
rpoC 767305 p.Tyr1312* stop_gained 0.24
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
embR 1416410 p.Leu313Arg missense_variant 1.0
atpE 1461019 c.-26C>A upstream_gene_variant 0.27
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1473343 n.1498G>T non_coding_transcript_exon_variant 0.18
rrl 1474380 n.723G>T non_coding_transcript_exon_variant 0.24
rrl 1475363 n.1706C>A non_coding_transcript_exon_variant 0.17
rrl 1476408 n.2751G>C non_coding_transcript_exon_variant 0.16
inhA 1674465 c.264C>T synonymous_variant 1.0
inhA 1674952 p.Pro251Ala missense_variant 0.15
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102891 p.Phe51Ser missense_variant 0.19
PPE35 2169866 c.747G>C synonymous_variant 0.26
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714366 p.Val323Leu missense_variant 0.2
ahpC 2726287 p.Gly32Asp missense_variant 1.0
pepQ 2859381 c.1038C>G synonymous_variant 0.26
Rv2752c 3064552 p.Arg547Pro missense_variant 0.24
Rv2752c 3064741 p.Gly484Ala missense_variant 0.21
thyA 3073806 c.666C>G synonymous_variant 0.17
thyA 3073817 p.Gln219Glu missense_variant 0.28
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3613029 c.88T>C synonymous_variant 1.0
fbiB 3641955 p.Gly141Arg missense_variant 0.22
fbiB 3642734 c.1200G>C synonymous_variant 0.17
clpC1 4038857 c.1848C>A synonymous_variant 0.18
clpC1 4039932 p.Gly258Val missense_variant 0.33
embC 4242476 p.Pro872Ala missense_variant 0.2
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242822 p.Val987Gly missense_variant 0.33
embA 4243190 c.-43G>C upstream_gene_variant 1.0
embA 4243709 c.477C>T synonymous_variant 1.0
embA 4244375 c.1143C>G synonymous_variant 0.24
embA 4245055 p.Thr608Asn missense_variant 1.0
ubiA 4269529 p.Ala102Gly missense_variant 0.23
ethA 4327672 c.-199G>A upstream_gene_variant 0.24
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
whiB6 4338635 c.-114A>C upstream_gene_variant 1.0
gid 4408115 p.Gly30Arg missense_variant 1.0