TB-Profiler result

Run: ERR046739
Summary

Run ID: ERR046739

Sample name:

Date: 31-03-2023 08:49:06

Number of reads: 7302359

Percentage reads mapped: 99.38

Strain: lineage4.1.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.1 Euro-American (X-type) X1;X2;X3 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7799 c.498A>C synonymous_variant 0.23
gyrA 8626 p.Arg442His missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
mshA 576751 p.Lys468Asn missense_variant 0.22
rpoC 762836 c.-534C>G upstream_gene_variant 0.16
rpoC 765150 p.Gly594Glu missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpR5 779371 p.Ala128Pro missense_variant 0.2
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
atpE 1461019 c.-26C>A upstream_gene_variant 0.24
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 1.0
rrl 1475363 n.1706C>A non_coding_transcript_exon_variant 0.27
rrl 1476408 n.2751G>C non_coding_transcript_exon_variant 0.17
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102891 p.Phe51Ser missense_variant 0.22
PPE35 2169866 c.747G>C synonymous_variant 0.39
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714366 p.Val323Leu missense_variant 0.37
eis 2715586 c.-254G>C upstream_gene_variant 0.5
Rv2752c 3064552 p.Arg547Pro missense_variant 0.16
Rv2752c 3064741 p.Gly484Ala missense_variant 0.22
ald 3086750 c.-70A>C upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474601 p.Arg199Gly missense_variant 0.27
fbiA 3641447 p.Thr302Met missense_variant 1.0
fbiB 3641955 p.Gly141Arg missense_variant 0.15
fbiB 3642734 c.1200G>C synonymous_variant 0.17
fbiB 3642772 p.Asp413Ala missense_variant 0.21
alr 3840268 p.Thr385Pro missense_variant 0.27
rpoA 3877553 p.Glu319Lys missense_variant 1.0
rpoA 3878559 c.-53_-52insC upstream_gene_variant 0.3
rpoA 3878601 c.-95delG upstream_gene_variant 0.26
ddn 3987013 p.Gly57Ala missense_variant 0.18
clpC1 4038857 c.1848C>A synonymous_variant 0.14
clpC1 4039932 p.Gly258Val missense_variant 0.23
embC 4240897 c.1035C>G synonymous_variant 1.0
embC 4241056 c.1194C>G synonymous_variant 0.24
embC 4241456 p.Ala532Pro missense_variant 0.43
embC 4242425 p.Arg855Gly missense_variant 0.16
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embC 4242822 p.Val987Gly missense_variant 0.33
embC 4242827 p.Leu989Val missense_variant 0.26
embA 4244118 p.Tyr296His missense_variant 1.0
embA 4244375 c.1143C>G synonymous_variant 0.18
embB 4248725 p.Ser738Ala missense_variant 0.23
embB 4249408 c.2895G>A synonymous_variant 1.0
ubiA 4269529 p.Ala102Gly missense_variant 0.26
ubiA 4269880 c.-48dupG upstream_gene_variant 0.99
ethA 4327672 c.-199G>A upstream_gene_variant 0.22
ethA 4328330 c.-858_-857insGC upstream_gene_variant 0.93
whiB6 4338595 c.-75delG upstream_gene_variant 1.0