TB-Profiler result

Run: ERR047007
Summary

Run ID: ERR047007

Sample name:

Date: 31-03-2023 09:01:00

Number of reads: 6585279

Percentage reads mapped: 99.71

Strain: lineage4.3.3

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.3 Euro-American (LAM) mainly-LAM None 0.98
lineage4.3.3 Euro-American (LAM) LAM;T RD115 0.98
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8040 p.Gly247Ser missense_variant 0.99
gyrA 9304 p.Gly668Asp missense_variant 0.99
rpoC 762836 c.-534C>G upstream_gene_variant 0.24
rpoC 764725 p.Phe452Leu missense_variant 0.28
rpoC 764995 c.1626C>G synonymous_variant 0.99
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpR5 779371 p.Ala128Pro missense_variant 0.22
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
atpE 1461019 c.-26C>A upstream_gene_variant 0.19
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1475363 n.1706C>A non_coding_transcript_exon_variant 0.28
rpsA 1834836 p.Met432Thr missense_variant 0.96
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2156196 c.-85C>T upstream_gene_variant 1.0
PPE35 2169866 c.747G>C synonymous_variant 0.42
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518919 p.Gly269Ser missense_variant 1.0
eis 2714366 p.Val323Leu missense_variant 0.29
eis 2715586 c.-254G>C upstream_gene_variant 0.29
folC 2746340 p.Ala420Val missense_variant 1.0
Rv2752c 3064552 p.Arg547Pro missense_variant 0.23
Rv2752c 3064741 p.Gly484Ala missense_variant 0.25
thyA 3073868 p.Thr202Ala missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 0.98
fbiD 3339550 p.Gly145Trp missense_variant 0.25
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiB 3642734 c.1200G>C synonymous_variant 0.15
rpoA 3878238 p.Asp90Glu missense_variant 0.18
clpC1 4038287 c.2418C>T synonymous_variant 0.98
clpC1 4038857 c.1848C>A synonymous_variant 0.18
clpC1 4038968 c.1737G>A synonymous_variant 0.99
clpC1 4039932 p.Gly258Val missense_variant 0.23
embC 4239842 c.-21C>A upstream_gene_variant 0.23
embC 4239973 c.111T>G synonymous_variant 0.22
embC 4242476 p.Pro872Ala missense_variant 0.32
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242822 p.Val987Gly missense_variant 0.47
embC 4242827 p.Leu989Val missense_variant 0.3
ubiA 4269529 p.Ala102Gly missense_variant 0.19
ethA 4327672 c.-199G>A upstream_gene_variant 0.31
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408156 p.Leu16Arg missense_variant 0.98