TB-Profiler result

Run: ERR11044538

Summary

Run ID: ERR11044538

Sample name:

Date: 31-03-2023 11:55:24

Number of reads: 4854253

Percentage reads mapped: 99.66

Strain: lineage4.6

Drug-resistance: RR-TB


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.6 Euro-American T;LAM None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761139 p.His445Asp missense_variant 1.0 rifampicin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
rpoB 760031 c.225C>T synonymous_variant 1.0
rpoC 763644 p.Met92Thr missense_variant 0.99
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 0.99
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rpsA 1834965 p.Glu475Gly missense_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918091 p.Ala51Gly missense_variant 1.0
PPE35 2168080 p.Thr845Ala missense_variant 1.0
PPE35 2170065 p.Ala183Gly missense_variant 0.19
PPE35 2170198 p.Ala139Thr missense_variant 1.0
PPE35 2170792 c.-180T>C upstream_gene_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
fbiD 3339734 p.Ala206Gly missense_variant 0.48
fbiD 3339746 p.Ala210Gly missense_variant 0.16
fprA 3473996 c.-11_-10insA upstream_gene_variant 0.99
fbiB 3642602 c.1068A>G synonymous_variant 1.0
rpoA 3878613 c.-106A>C upstream_gene_variant 0.16
rpoA 3878618 c.-111A>C upstream_gene_variant 0.27
rpoA 3878637 c.-130G>C upstream_gene_variant 0.18
rpoA 3878641 c.-134C>G upstream_gene_variant 0.35
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246584 p.Arg24Pro missense_variant 0.31
embB 4248324 p.Ala604Gly missense_variant 0.21
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408114 p.Gly30Val missense_variant 0.99