TB-Profiler result

Run: ERR11067909
Summary

Run ID: ERR11067909

Sample name:

Date: 2024-04-16T04:07:05.147747

Number of reads: 3361907

Percentage reads mapped: 99.63

Median coverage: 98.0

Strain: lineage4.1.2.1;lineage4.8

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.43
lineage4.1.2 Euro-American None 0.45
lineage4.1.2.1 Euro-American (Haarlem) RD182 0.42
lineage4 Euro-American None 1.0
lineage4.8 Euro-American (mainly T) RD219 0.59
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 0.47 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 0.32 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491591 p.Lys270Met missense_variant 0.39 clofazimine Not assoc w R
pretomanid
delamanid Uncertain significance
mshA 575679 p.Asn111Ser missense_variant 0.39 ethionamide Not assoc w R
isoniazid Not assoc w R
Rv0565c 656265 c.1204_1205delAC frameshift_variant 0.61 ethionamide Uncertain significance
Rv0565c 657269 p.Ser68Pro missense_variant 0.31 ethionamide Uncertain significance
nusG 734658 c.405A>G synonymous_variant 0.59 rifampicin Not assoc w R
rpoB 760115 c.309C>T synonymous_variant 0.4 rifampicin Not assoc w R
rpoC 765150 p.Gly594Glu missense_variant 0.53 rifampicin Not assoc w R
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
Rv1129c 1253330 p.Gly402Glu missense_variant 0.49 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.63 capreomycin Not assoc w R
linezolid Not assoc w R
tsnR 1854300 p.Leu232Pro missense_variant 0.46 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1918640 p.Ser234Leu missense_variant 0.42 capreomycin
katG 2154617 p.Leu499Met missense_variant 0.54 isoniazid
PPE35 2168149 p.Pro822Ser missense_variant 0.59 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518076 c.-39C>T upstream_gene_variant 0.4 isoniazid
Rv2680 2995848 c.-257G>A upstream_gene_variant 0.5 capreomycin
ald 3086788 c.-32T>C upstream_gene_variant 0.47 cycloserine
Rv3236c 3613636 c.-520A>G upstream_gene_variant 0.54 pyrazinamide Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 0.3 bedaquiline Uncertain significance
rifampicin Not assoc w R
clpC1 4039729 p.Asp326Asn missense_variant 0.66 pyrazinamide Not assoc w R
embC 4239298 c.-565C>T upstream_gene_variant 0.46 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.42 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 0.4 capreomycin
amikacin
kanamycin